The presence of chloroquine-resistant Plasmodium vivax malaria in the New World has been suspected but not confirmed. We report the cases of three patients who acquired vivax malaria in Guyana, South America, and for whom standard chloroquine therapy (25 mg/kg) failed despite therapeutic blood levels. The optimal treatment of chloroquine-resistant P. vivax malaria is unknown, but recent studies...

Hybridomas producing monoclonal antibodies (MAbs) directed against P. vivax erythrocytic stage antigens were isolated. Here, we describe the production of six MAbs. Culture supernatant from growing hybridomas was tested for their reactivity with P. vivax erythrocytic stages by ELISA against P. vivax crude (PvC) antigen and by immunofluorescence assay on P. vivax infected erythrocyte smears. P. ...

Plasmodium vivax is not thought to be transmitted in western and central Africa, because of the very high prevalence of the red blood cell Duffy-negative phenotype in local populations, a condition which is thought to confer complete resistance against blood infection with P. vivax. There are, however, persistent reports of travelers returning from this region with P. vivax infections. To inves...

background: approximately 85-90% of malaria infections in iran are attributed to plasmodium vivax , while little is known about the genetic of the parasite and its strain types in this region. this study was designed and performed for describing genetic characteristics of plasmodium vivax population of iran based on the merozoite surface protein-3α gene sequence. methods: through a descriptive ...

Approximately 55% of malaria infections in the Guyana Amazon region are attributed to Plasmodium falciparum while the other 45% are attributed to non-falciparum, mostly Plasmodium vivax. However, little is known about the P. vivax strain types circulating in the region. Using PCR for Plasmodium detection and two genetic markers specific to P. vivax to detect the polymorphic circumsporozoite pro...

INTRODUCTION Severe malaria due to P. vivax infection is increasingly observed now a days. Organ failure in vivax malaria is caused by mechanisms of inflammation as well as sequestration. In this study we have compared the complications in vivax malaria with those in falciparum or mixed malaria. AIMS AND OBJECTIVES 1) To study various complications in adult inpatients of vivax malaria. 2) To ...

BACKGROUND Plasmodium vivax is the most widely distributed human malaria parasite with an at risk population of 2.5 billion persons. With the implementation of molecular diagnosis, it has become evident that P. vivax monoinfection could also result in multiple organ dysfunction and severe life-threatening disease as seen in P. falciparum infection. AIMS AND OBJECTIVES To note the clinical pro...

Our survey showed P. vivax seropositivity in 5 of the 6 nonhuman primate centers in southern China, which is a potential health problem for bred cynomolgus monkeys. This fi nding also indicates the risk for infection with P. vivax for the employees of these nonhuman primate centers. Therefore, studies are warranted that assess the seroprevalence of P. vivax infection in persons who work in thes...

Infection by Trypanosoma vivax and other African trypanosomes plays an important role in reproductive disorders in male and female livestock. Outbreaks of T. vivax in the semi-arid region of northeastern Brazil are characterized by wasting disease in cattle, sheep and goats with hematological, cardiac and nervous compromises in addition to reproductive failures. Similar to reports from Africa, ...

Plasmodium vivax is the second most prevalent parasite species causing malaria in humans living in tropical and subtropical areas throughout the world. There have been few P. vivax proteomic studies to date and they have focused on using clinical isolates, given the technical difficulties concerning how to maintain an in vitro culture of this species. This study was thus focused on identifying ...