Introduction: Hereditary Gingival Enlargement (HGF), a rare entity, is also known as familial elephantiasis, elephantiasis gingivae, diffuse fibromatosis. It benign, non-haemorrhagic fibrous enlargement of gingival tissue. frequently component feature many syndromes. Jones syndrome one such syndrome, characterized by overgrowth and progressive deafness.
 Case report: A 27-year-old male pat...

Regulation of spatio-temporal gene expression in diverse cell and tissue types is a critical aspect of development. Progression through Caenorhabditis elegans vulval development leads to the generation of seven distinct vulval cell types (vulA, vulB1, vulB2, vulC, vulD, vulE, and vulF), each with its own unique gene expression profile. The mechanisms that establish the precise spatial patternin...

A new record species Heterodera ripae was found in the rhizosphere soil of nettle (Urtica sp.) on the bank of the Mangniu River in Shenyang City, Liaoning Province, China. The new record species can be characterized by vulval cone bifenestrate with circular or subcircular semifenestrae, vulval slit length averaging 34.2 μm, vulval bridge mostly broad, underbridge weak, bullae absent; the second...

During vulval development in the Caenorhabditis elegans hermaphrodite, the fates of six vulval precursor cells (VPCs) are influenced by distinct cell signaling events. In one event, a somatic gonadal cell, the anchor cell, induces the three nearest VPCs to adopt vulval cell fates. In another event, lateral signaling between adjacent VPCs specifies one of two different vulval fates, 1 degrees an...

The Notch signaling pathway controls growth, differentiation and patterning in divergent animal phyla; in humans, defective Notch signaling has been implicated in cancer, stroke and neurodegenerative disorders. Despite its developmental and medical significance, little is known about the factors that render cells to become competent for Notch signaling. Here we show that during vulval developme...

Intercellular cell-survival signals play a major role in animal development [1]. In the nematode Caenorhabditis elegans, however, the stereotyped cell deaths that occur reproducibly during development are regulated in a cell-autonomous fashion (or, in a few cases, by a death-inducing signal) [2]. We show here the existence of a cell-survival signal acting on the vulval precursor cells in two ne...

Chromatin-modifying complexes are important for transcriptional control, but their roles in the regulation of development are poorly understood. Here, we show that components of the nucleosome remodelling and histone deacetylase (NURD) complex [1] [2] [3] [4] [5] antagonise vulval development, which is induced by the Ras signal transduction pathway. In three of the six equivalent vulval precurs...

We measured the concentrations of several circulating fibrosis markers (type I collagen I, type III procollagen, hyaluronan) and eosinophil granule proteins (ECP and EPX) in lymphatic filariosis patients to investigate their relationship with clinical, parasitological and immunological data. This study was conducted in Polynesian patients with various stages of the disease (acute lymphangitis, ...