Telomere attrition is a natural process that occurs due to inadequate telomere maintenance. Once at a critically short threshold, telomeres signal the cell to cease division and enter a cell fate termed senescence. Telomeres can be elongated by the enzyme telomerase, which adds de novo telomere repeats to the ends of chromosomes. Mutations in the telomerase complex or telomere-related genes giv...

Recently, the capital expenditure of flash-based Solid State Driver (SSDs) keeps declining and storage capacity SSDs increasing. As a result, all-flash systems have started to become more economically viable for large shared installations in datacenters, where metrics like Total Cost Ownership (TCO) are paramount importance. On other hand, flash devices suffer from write amplification, which, i...

The effects of wheat and rye breads made from whole-wheat grain (WWG), wheat aleurone flour (WAF) or rye aleurone flour (RAF) on net portal absorption of carbohydrate-derived nutrients (glucose, SCFA and lactate) and apparent insulin secretion were studied in a model experiment with catheterised pigs. The breads were similar in dietary fibre (DF, 120-125 g/kg DM) but differed in arabinoxylans (...

The term vitamin E refers to a group of eight lipophilic compounds known as tocochromanols. The tocochromanols are divided into two groups, that is, tocopherols and tocotrienols, with four forms each, namely α-, β-, γ-, and δ-. In order to explore the temporal biosynthesis of tocochromanols in olive (Olea europaea cv. 'Koroneiki') fruit during on-tree development and ripening over successive gr...

We study stability properties and truncation errors of the finite-volume ADER schemes on structured meshes as applied to the linear advection equation with constant coefficients in one-, twoand threespatial dimensions. Stability of linear ADER schemes is analysed by means of the von Neumann method. For nonlinear schemes, we deduce the stability region from numerical experiments. The truncation ...

PURPOSE Uveal melanoma (UM) is the most common primary malignant ocular tumor in adults. No effective chemotherapy regimens are available for either intraocular or metastatic uveal melanoma. Therefore, the ability of the histone deacetylase inhibitors (HDACIs), depsipeptide, sodium butyrate (NaB) and trichostatin A (TSA), to induce apoptosis and inhibit cell growth of UM cell lines in vitro was...