There is a compelling need to discover type II inhibitors targeting the unique DFG-out inactive kinase conformation since they are likely to possess greater potency and selectivity relative to traditional type I inhibitors. Using a known inhibitor, such as a currently available and approved drug or inhibitor, as a template to design new drugs via computational de novo design is helpful when wor...

neospora caninum is an intracellular parasite which causes abortion in cattle worldwide. The aim of this study was to determine the seroprevalence of neospora caninum in cattle in the province of Kerman in South East Iran. Blood samples were collected from 285 cattle in the province of Kerman for determining the seroprevalence of neospora caninum. A total of 285 serum samples were tested for an...

INTRODUCTION .......................................................................... DNA SUPERCOILING AND TOPOISOMERASES ............................................. CONTROL OF TOPOISOMERASE GENE EXPRESSION ...................................... ROLE OF TOPOISOMERASES AND SUPERCOILING IN DNA REPLICATION................. Elongation Phase of Replication ..........................................

BACKGROUND Previous study showed that dsP53-285 has the capacity to induce tumor suppressor gene p53 expression by targeting promoter in non-human primates' cells. And it is well known that TP53 gene is frequently mutant or inactivated in human bladder cancer. Hereby, whether this small RNA can activate the expression of wild-type p53 and inhibit human bladder cancer cells remains to be elucida...