Lethal challenge of gnotobiotic weanling rats I am surprised that a more critical appraisal of the paper by Lee et al' was not made prior to publication. The paper is poorly constructed and the conclusions invalid. The mixing of the commensal organisms obtained from the nasopharynx of different infants who had died as a result of SIDS, and injecting them subcutaneously in high concentrations (l...

BACKGROUND/AIMS Endothelium-dependent dilation of skeletal muscle arterioles is mediated by unknown factors in very young rats. We assessed the possible contribution of carbon monoxide (CO) to this dilation and to dilation in older animals. METHODS The effects of de-endothelialization or various pharmacological inhibitors on responses to CO or endothelium-dependent dilators were studied in gr...

Weanling outbred rats were infected with Cryptococcus neoformans by direct percranial puncture and inoculation into the cranium. A lethal infection ensued. Treatment with LY295337, a depsipeptide with antifungal activity, was effective in prolonging survival and reducing fungal counts in brain tissue. Weanling rats are an acceptable model for the study of central nervous system infection with C...

Mouse models have been indispensable for elucidating normal and pathological processes that influence learning and memory. A widely used method for assessing these cognitive processes in mice is the Morris water maze, a classic test for examining spatial learning and memory. However, Morris water maze studies with mice have principally been performed using adult animals, which preclude studies ...

in this study the plasma levels of lipid peroxidation (lp) products, protein carbonyls and antioxidant capacity of plasma as judged by ferric reducing ability of plasma (frap assay) were compared in adult and weanling rats treated with vitamin k1 phylloquinone).

This study was designed to determine whether juvenile growth is accompanied by changes in the local influence of nitric oxide (NO) or prostaglandins on arteriolar tone. In vivo microscopy was used to study proximal arterioles in the spinotrapezius muscle of rats 4-5 wk (weanling), 7-8 wk (juvenile), and 11-12 wk (mature) of age. From 4 to 12 wk of age, arterioles underwent an increase in restin...

Diarrhoea is a major public health problem in Thailand. During November 1998-January 1999, a cross-sectional survey and a nested qualitative study were conducted to understand the relationship between feeding practices and weanling diarrhoea, and to describe the related local beliefs and practices in a subdistrict of northeast Thailand. A cluster-sampling method was used for selecting 156 weanl...

The effect of substituting pelleted diets with multinutrient block on the growth weanling rabbits was studied. and blocks contained crude protein 23.31% 24.24%, fibre 21.65 23.00% ether extract 10.44% 10.97% respectively. body weight gain (10.58g/day), feed intake (110,20g/day) efficiency ration (0.58) fed were non-significantly higher by 8.50%, 10.65% 10.34% respectively, that those basal diet.