A study involving 825 spring ewe lambs was conducted to evaluate effects of breed, heterosis, type of birth and rearing, age of dam and preweaning and postweaning growth rate on occurrence of puberty before November 10. Within a breed or breed-cross, preweaning competition among twin and triplet lambs reduced lamb weights by 4 or 5 kg at 70 (weaning), 160 and 230 days of age and by about 3 kg a...

Two experiments were conducted to quantify the effects of lasalocid on the performance and energy partitioning of cattle fed a 90% concentrate, barley-based diet. Experiment 1 utilized 100 Hereford heifers (initial weight 308 kg) fed diets containing no added ionophore, lasalocid added at 24, 36 or 54 mg/kg dry matter (DM), or monensin added at 33 mg/kg DM. In the 98-d trial, lasalocid-fed heif...

2) sows receiving 1 g/kg of MOS during lactation, and dietary treatment: 1) basal diet (control), and 2) basal diet with MOS at 2 g/kg in prestarter and 1 g/kg in starter diets. The experimental design was applied in both the prestarter (28 to 44 d of age) and the starter (44 to 60 d of age) periods. Nutritive value of the diets was 2.5 Mcal NE/kg and 14.8 g/kg lysine for prestarter, and 2.5 Mc...

The objective of this study was to determine whether physiological testosterone replacement increases fat-free mass (FFM) and muscle strength and contributes to weight maintenance in HIV-infected women with relative androgen deficiency and weight loss. Fifty-two HIV-infected, medically stable women, 18-50 yr of age, with more than 5% weight loss over 6 months and testosterone levels below 33 ng...

Direct oral anticoagulants are administered in fixed doses irrespective of body weight, but guidelines recommend against their use patients with extremes weight. This study determined the effects dual-pathway inhibition antithrombotic regimen (rivaroxaban 2.5 mg twice daily plus aspirin 100 mg/day) compared Halone across a range patient mass indexes (BMIs) and weights. was secondary analysis CO...

Hyaluronan-binding function of the CD44 molecule has not been so far detected in myeloid cells. To study pure populations of primitive myeloid cells, we investigated the hyaluronan-binding function of the CD44 molecule from three myeloid cell lines: KGla, KGI, and HL60. Both KGla and KG1 cells express the CD34 antigen characteristic of the hematopoietic stem cells and HL60 cells do not; accordi...

OBJECTIVES Aripiprazole modulates dopaminergic and serotonergic pathways that may play a role in the pathogenesis of Tourette's disorder (TD). This trial evaluated the efficacy and safety of oral aripiprazole in the suppression of tics in children and adolescents with TD. METHODS This phase 3, randomized, double-blind, placebo-controlled trial ( ClinicalTrials.gov , NCT01727700) recruited pat...

Aim: The COVID-19 "lockdown process" can cause weight gain due to sedentary lifestyle, dietary and sleep disturbances. In this study, we aimed determine clinical metabolic effects of change in obese patients caused by the quarantine. Methods: This study included 44 with a BMI 30 kg/m2. patients’ pre-quarantine parameters were obtained from hospital records. measured again after Patients questio...

Background: Cortical spreading depolarization (CSD) is associated with poor outcomes following traumatic brain injury (TBI). Here we aimed to: (1) determine the effect of NMDA-receptor antagonism on CSDs in healthy and TBI animals vivo ; (2) conduct a randomized pre-clinical trial (RCT) memantine for prevention neurological decline repetitive mild (rmTBI). Methods: Rodents received either one m...

In eukaryotes, aberrant expression of transposable elements (TEs) is detrimental to the host genome. Piwi-interacting RNAs (piRNAs) of ∼23 to 30 nucleotides bound to PIWI clade Argonaute proteins silence transposons in a manner that is strictly dependent on their sequence complementarity. Hence, a key goal in understanding piRNA pathways is to determine mechanisms that modulate piRNA sequences....