Dissolution behaviour of a poorly water-soluble drug, tadalafil, from its solid dispersion systems with poloxamer 407 has been investigated. Solid dispersion systems of tadalafil were prepared with poloxamer 407 in 1:0.5, 1:1.5 and 1:2.5 ratios using the melting method. Characterization of binary systems with FTIR and XRPD studies demonstrated the presence of strong hydrogen bonding interaction...

BACKGROUND Coronary occlusion techniques during OPCAB may lead to an endothelial damage to the target vessel. The adverse effects of these techniques are well-known, and researches have been trying to find out new materials to occlude the coronary artery without an endothelial damage. In the present study, we investigate to the endothelial damage in the rat aorta which is occluded by Poloxamer ...

Bu çalışma 2021 yılında Denizli ilinin Tavas ilçesine bağlı Nikfer Köyü’nde bulunan üretici tarlasında Ege Bölgesi tütün fidelerine uygulanan sıvı organik gübrenin verim ve komponentleri ile bazı kalite özellikleri üzerine etkisini belirlemek amacıyla yürütülmüştür. Sarıbağlar 407 çeşidinin kullanıldığı araştırma Tesadüf Blokları Deneme Deseni’ ne göre üç tekerrürlü olarak gerçekleştirilmiştir....

BACKGROUND Delivery of a high concentration of anticancer drugs specifically to cancer cells remains the biggest challenge for the treatment of multidrug-resistant cancer. Poloxamers and D-α-Tocopheryl polyethylene glycol 1000 succinate (TPGS) are known inhibitors of P-glycoprotein (P-gp). Mixed micelles prepared from Poloxamer 407 and TPGS may increase the therapeutic efficacy of the drug by d...

Mycotoxins – General SCUDAMORE, K.A. and PATEL, S. 2000. Survey for aflatoxins, ochratoxin A, zearalenone and fumonisins in maize imported into the United Kingdom. Food Additives and Contaminants 17: 407–416. Raw maize as received at ports or at major maize mills in the UK were examined for aflatoxins B 1 , B 2 , G 1 and G 2 , ochratoxin A (OA), zearalenone (ZEA) and fumonisins B 1 , B 2 and B ...

The effects of atorvastatin and carboxymethylated β-glucan (CMG) on the lipoprotein-cholesterol (LP-C) and lipoprotein-triglyceride (LP-TG) fractions and subfractions at the early stage of murine hyperlipidemia, and its pleiotropic anti-inflammatory effects, were studied. Atorvastatin and CMG were administered in ICR male mice with acute lipemia induced with a single injection of poloxamer 407 ...