نتایج جستجو برای: weinberg equilibrium were conducted using chi
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BACKGROUND Nodal/TGF-Lefty signaling pathway has important effects at early stages of differentiation of human embryonic stem cells in directing them to differentiate into different embryonic lineages. LEFTY, one of transforming growth factors in the Nodal/TGF-Lefty signaling pathway, plays an important role in the development of heart. The aim of this work was to find evidence on whether Lefty...
We conducted a case-control study to investigate the role of XPG gene polymorphisms (rs2094258, rs751402, and rs17655) in the development of breast cancer. Patients with breast cancer (320) and control subjects (294) were consecutively selected from the Zhongshan Hospital between April 2013 and January 2015. The genotyping of XPG rs2094258, rs751402, and rs17655 was performed using polymerase c...
BACKGROUND The human heart consists of several cell types with distinct lineage origins. Interactions between these cardiac progenitors are very important for heart formation. The muscle segment homeobox gene family plays a key role in the cell morphogenesis and growth, controlled cellular proliferation, differentiation, and apoptosis, but the relationships between the genetic abnormalities and...
BACKGROUND To date, research examining the relationship between serotonergic genes and obsessive-compulsive disorder (OCD) has yielded conflicting results. The purpose of this study is to investigate the association between four serotonergic polymorphisms (STin2 VNTR and 5-HTTLPR of the SLC6A4 gene, and A-1438G (rs6311) and T102C (rs6313) of the HTR2A gene) and OCD. METHODS 99 OCD patients, 4...
The purpose of this study was to determine the G>C mutation on exon 9 (G21234C) Bovine Smoothened (SMO) gene polymorphism by using Cfr13I restriction enzyme with PCR-RFLP method in both Anatolian Black cattle and Water Buffaloes. According SMO gene, results showed that there were three genotypes such as GG, GC CC cattle, but only one genotype GG Allele frequencies estimated 0.35 0.65 for G C...
in recent years, the relationship between insertion and deletion (indel) polymorphisms in promoter region (23 bp) and intron 1 (12 bp) of prnp gene (prion protein coding gene) and their relationship to susceptibility of classical bovine spongiform encephalopathy (bse) have been reported. insertions of these two polymorphisms increase resistance to classical bse, while the deletions of these two...
This paper considers the analysis of genetic case-control data. One approach considers the allele frequency in cases and controls. Because each individual has two alleles at any autosomal locus, there will be twice as many alleles as people. Another approach considers the risk of the disease in those who do not have the allele of interest (A), those who have a single copy (heterozygous), and th...
The CACNA2D1 gene encodes the protein and, this is involved in excitation-contraction mechanism of muscle cells during milk withdrawal, helps nipples to open and close. Because role physiological its relationship with quantitative trait locus (QTL) regions, known be associated mastitis resistance. In study, it was aimed investigate between different three SNP (C367400T, A496561G G519663A) on ge...
urokinase might play a role in the formation of kidney stones. this study was done to determine the association between +4065 t/c polymorphism at the 3′-untranslated region of urokinase gene and calcium kidney stones. this case-control study was carried out on 70 cases with a history of calcium kidney stones and 70 controls from the baqiyatallah hospital of tehran in 2013. the study of polymorp...
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