The objective of this study is to design and evaluate Ziprasidone Floating pellets, which prolongs the release rate drug while extending residence time within body environment without causing undeliterious effects subject. controlled matrix polymer granules were prepared by different granulation techniques in ratio 1:1, 1:1.5 1:2.Ziprasidone multi unit formulations comprising cellulose polymers...

This work describes a melt granulation technique to improve the solubility and dissolution characteristics of a poorly water-soluble drug Fenofibrate (FNO). Melt granulation technique is a process by which pharmaceutical powders are efficiently agglomerated by a meltable polymers and surfactants. The advantage of this technique compared to a conventional granulation is that no water or organic ...

During wet granulation, the sample can be exposed to considerable mechanical effects, moisture content and elevated temperatures, during high-shear granulation impeller chopper speeds induce temperatures influence parameters of products. In our work, we therefore aimed investigate effect cooling process on product by factorial design in accordance with QbD guidelines. Our other goal was study t...

In recent years, the interest in melt granulation has increased due to the advantages of this technique respect to traditional wet granulation; utilizable equipments for melt granulation are high-shear mixer and fluidised bed [1]. The aim of the study was to evaluate, by asymmetrical factorial design [2], the contribution of some variables on the in situ melt granulation process performed in fl...

   Aim of this research work was to develop mouth dissolving tablet that disintegrates rapidly in mouth by using tasteless complex of Levocetirizine and Tulsion-335. Effect of different parameters such as swelling time, resin activation, drug resin ratio as well as stirring time was optimized by taste and percentage drug loading. Formulated DRC (Drug Resin Complex) was characterized by infrared...

Wet granulation lines in pharmaceutical manufacturing facilities typically comprise a dryer that removes the excess moisture content after wet granulation. In this study, semi-continuous installed ConsiGma 25 line was investigated. The goal to highlight specific characteristics of type dryer, utilizing available process data and corresponding obtained via material characterization. This paper a...

Wet granulation is a key step in the pharmaceutical manufacturing of solid-dosage forms. used production to enhance formulation qualities such as flowability, compressibility, etc. Different methods are for wet granulation, including fluidised bed, twin-screw extrusion, and high-shear method, leading different mechanisms granule properties. Modelling great importance industry, which aspiring sh...