Homologs to mammalian nitric oxide synthases are found in many mostly Gram-positive bacteria. In some genera such as bacilli, and staphylococci, these enzymes produce protects against oxidative damage, this effect has now been shown to provide an advantage against antibiotics that kill by increasing cellular levels of reactive oxygen species.

• Increased consumer focus on sleep by education, regulation and patient selfawareness.7 Sleep medicine is a relatively new field that was officially recognized in the 1960s. Today, an estimated 50 million to 70 million Americans suffer from sleep-related problems.1 The first sleep disorder clinic was opened in 19702 at Stanford University by William Dement, MD. Today more than 2,000 sleep cent...