Inhibition of postsynaptic glutamate receptors at the Drosophila NMJ initiates a compensatory increase in presynaptic release termed synaptic homeostasis. BMP signaling is necessary for normal synaptic growth and stability. It remains unknown whether BMPs have a specific role during synaptic homeostasis and, if so, whether BMP signaling functions as an instructive retrograde signal that directl...

A bstract . We deal in this paper wit h the di fficul ty of per for ming opt imal or nearl y optimal forecasts of discrete symbol sequences generated by very simp le models . T hese are spatial sequences gene rated by elementary one-dimensional cellular automata. after one time step , wit h com pletely ran dom input st rings . T hey have p ositi ve entropy and t hus cannot be ent irely predict ...

This article presents a general method to use information retrieved from the Latent Dirichlet Allocation (LDA) topic model for Text Segmentation: Using topic assignments instead of words in two well-known Text Segmentation algorithms, namely TextTiling and C99, leads to significant improvements. Further, we introduce our own algorithm called TopicTiling, which is a simplified version of TextTil...

This paper investigates how sentence stresses are allocated within disyllabic prosodic words in Mandarin. By analyzing the results of a perceptual experiment on sentence stress, three factors i.e., stress type, word constitution and tone identity, which are probably related to sentence stress, are investigated . The authors argue that (1) semantic stresses tend to locate on the initial syllable...

LINC (linker of nucleoskeleton and cytoskeleton) complexes play an essential role in nuclear migration by connecting the nucleus to the cytoskeleton and/or motor proteins. Plant LINC complexes have recently been identified in Arabidopsis thaliana, with the inner nuclear membrane SUN and outer nuclear membrane WIP proteins comprising the first identified complex. A recent study identified a nucl...

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Here, we demonstrate that the BMP receptor Wishful Thinking (Wit) is required for synapse stabilization. In the absence of BMP signaling, synapse disassembly and retraction ensue. Remarkably, downstream Smad-mediated signaling cannot fully account for the stabilizing activity of the BMP receptor. We identify LIM Kinase1 (DLIMK1)-dependent signaling as a second, parallel pathway that confers the...

We extend Reiter’s general theory of model-based diagnosis [Reiter, 19871 to a theory of reconfiguration. The generality of Reiter’s theory readily supports an extension in which the problem of reconfiguration is viewed as a close analogue of the problem of diagnosis. Using a reconfiguration predicate rcfg analogous to the abnormality predicate ab, we formulate a strategy for reconfiguration by...