Therapeutic antibodies are widely used for disease detection and specific treatments. However, as an exogenous protein, these antibodies can be detected by the human immune system and elicit a response that can lead to serious illnesses. Therapeutic antibodies can be engineered through antibody humanization, which aims to maintain the specificity and biological function of the original antibodi...

The scope of this study was to assess user evaluation about dental care in the Unified Health System and analyze the associations between this evaluation, sociodemographic characteristics, and aspects related to humanization of the services. It involved a cross-sectional survey with a quantitative approach, in which 461 users responded to individual interviews. The outcome variable was obtained...

In recent years, the rapid growth of wireless communications has undoubtedly increased the need for speech recognition techniques. In wireless environments, the portability of a computationally powerful device can be realized by distributing data/information and computation resources over wireless networks. Portability can then evolve through personalization and humanization to meet people’s ne...

Immune responses to some monoclonal antibodies (mAbs) and biologic proteins interfere with their efficacy due to the development of anti-drug antibodies (ADA). In the case of mAbs, most ADA target 'foreign' sequences present in the complementarity determining regions (CDRs). Humanization of the mAb sequence is one approach that has been used to render biologics less foreign to the human immune ...

Objectives Nanobodies, the single domain antigen binding fragments of heavy chain-only antibodies occurring naturally in camelid sera, are the smallest intact antigen binding entities. Their minimal size assists in reaching otherwise largely inaccessible regions of antigens. However, their camelid origin raises a possible concern of immunogenicity when used for human therapy. Humanization is a ...

Israel has provided immediate healthcare to Syrian children, civilians and fighters since early 2013 despite being in an official state of war with Syria since 1973. We present qualitative findings from a larger mixed-methods phenomenological study to understand how the geopolitical and social history of Israel and Syria influences healthcare providers and Syrian patient caregivers in northern ...

The purpose of this paper is to prompt discussions of the perspectives of the Evaluation of Brazil's National Health Humanization Policy being implemented by the Ministry of Health (PNH/HumanizaSUS). It strives to systemize some Health Evaluation benchmarks, distinguishing two key aspects of this evaluation: one examines methodologies for the definition of Humanization actions monitoring indica...

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The article is devoted to the search for formal criteria of economic humanization in new millennium. fields and limits a human-oriented economy are defined as such criteria. Fields considered system relations which socio-economic human rights realized. As results comparative analysis, it established that list characterized by constant development. set these most clearly outlined today Sustainab...