Regeneration requires signaling from a wound site for detection of the wound and a mechanism that determines the nature of the injury to specify the appropriate regenerative response. Wound signals and tissue responses to wounds that elicit regeneration remain poorly understood. Planarians are able to regenerate from essentially any type of injury and present a novel system for the study of wou...

Tissue injury can lead to scar formation or tissue regeneration. How regenerative animals sense initial tissue injury and transform wound signals into regenerative growth is an unresolved question. Previously, we found that the Src family kinase (SFK) Lyn functions as a redox sensor in leukocytes that detects H(2)O(2) at wounds in zebrafish larvae. In this paper, using zebrafish larval tail fin...

A case of a transcranial stab wound is presented in which the patient was stabbed in the left temporal bone with a knife which, after traversing the tentorium, passed through the occipital squama and its tip reached the upper cervical area. The subject underwent surgery and was discharged without neurological sequelae. The fundamental principles of management in this specific type of head ...

BACKGROUND Idiopathic pulmonary fibrosis (IPF) is a progressive disorder marked by relentless fibrosis and damage of the lung architecture. A growing body of evidence now suggests that IPF progresses as a result of aberrant epithelial-fibroblast crosstalk. Injured epithelia are a major source of growth factors such as PDGF which guide resident fibroblasts to injury sites. RESULTS In this stud...

conceptually traumatic brain injury (tbi) can be classified from a mechanistic perspective as: 1) closed, 2) penetrating, 3) blast, and 4) crush injuries. thus, tbi is a heterogeneous disease and each type of brain injury has different characteristic features often necessitating different approaches to management. the first edition of the guidelines for management and prognosis of penetrating b...

introduction: opium addiction can change immune response to types of stress such as injury or trauma due to alterations in the in secretion status of cytokines in the body. in this study, effects of opium addiction on wound healing and post-operative adhesion bands were assessed after laparotomy. materials and methods: male rats (n=20) were randomly divided into opium addicted (documented with ...

  Background: Wound complications following open repair for acute Achilles tendon ruptures (AATR) remain the subject of significant debate. The aim of this study is to investigate the effects of covering repaired AATR using well-nourished connective tissues (paratenon and deep fascia) to avoid complications after open repair.   Methods: In this case series study, open repair was performed for 3...

spinal cord injury (sci) results in the damage of motor and sensory pathways. the molecular and cellular structure of the injury milieu has been shown to be vital for endogenous regeneration in most tissues. regeneration of injured central nervous system (cns) is limited by damaged cell environment. biomaterial scaffolds can reconstruct injured cns tissue following sci by promoting the migratio...

The goals of emergency wound treatment are to restore function, repair tissue integrity with strength and optimal cosmetic appearance, and minimize risk of infection. Risk of infection depends on the location, mechanism, host, and care. The risk for a clean facial wound produced by incision is less than 1%, whereas a dirty crush injury to the lower extremity may have more than a 20% risk. Wound...