This review summarizes the involvement of centrally and peripherally applied melatonin, a major hormone of pineal gland, in the mechanism of gastric mucosal integrity, gastroprotection and ulcer healing. Melatonin was originally shown to attenuate gastric mucosal lesions but the controversy exists in the literature as to whether melatonin derived from the pineal gland, considered as the major s...

Wolcott-Rallison syndrome (WRS) and the recently delineated microcephaly with simplified gyration, epilepsy, and permanent neonatal diabetes syndrome (MEDS) are clinically overlapping autosomal recessive disorders characterized by early onset diabetes, skeletal defects, and growth retardation. While liver and renal symptoms are more severe in WRS, neurodevelopmental characteristics are more pro...

Wolcott-Rallison syndrome (WRS) is an autosomal recessive disorder characterized by neonatal or early infancy type 1 diabetes, epiphyseal dysplasia, and growth retardation. Mutations in the EIF2AK3 gene, encoding the eukaryotic initiation factor 2alpha-kinase 3 (EIF2AK3), have been found in WRS patients. Here we describe a girl who came to our attention at 2 months of age with severe hypertonic...

Tracking the evolution of research in waste recycling science (WRS) can be valuable for environmental agencies, as well as for recycling businesses. Maps of science are visual, easily readable representations of the cognitive structure of a branch of science, a particular area of research or the global spectrum of scientific production. They are generally built upon evidence collected from reli...

We present new low and intermediate-resolution spectroscopic observations of the Wolf Rayet (WR) star population in the massive starburst cluster Westerlund 1. Finding charts are presented for five new WRs – four WNL and one WCL – raising the current total of known WRs in the cluster to 19. We also present new spectra and correct identifications for the majority of the 14 WR stars previously kn...

In this research, an autonomous control system for blimp navigation was developed using reinforcement learning algorithm. The aim of this research is to provide a blimp the capability to approach a goal position autonomously in an environment, where the dynamical models of the blimp and the environment are unknown. WebotsTM Robotics Simulator (WRS) was used to simulate and evaluate the control ...

Creep-cyclic plasticity and creep-fatigue damage interaction of a welded flange are studied considering both the thermo-mechanical load welding residual stress (WRS). The presence WRS was found to have minimal effect on shakedown ratcheting curves, though distribution changes considerably in WRS. is predominant for initial cycles after which it relaxes so that at steady state creep-cyclic respo...

Wolcott-Rallison syndrome (WRS) is a rare autosomal recessive disease, characterized by neonatal/early-onset non-autoimmune insulin-requiring diabetes associated with skeletal dysplasia and growth retardation. Fewer than 60 cases have been described in the literature, although WRS is now recognised as the most frequent cause of neonatal/early-onset diabetes in patients with consanguineous paren...

Wolcott-Rallison Syndrome is the commonest cause of neonatal diabetes in consanguineous families. It is associated with liver dysfunction, epiphyseal dysplasia, and developmental delay. It is caused by mutations in eukaryotic translation initiation factor 2-α kinase 3 (EIF2AK3).We report 4 children with WRS and Os Odontoideum resulting in significant neurological compromise. This cervical spine...