In reading 3, we described a correspondence between predicates on one variable and sets. A predicate defines a set, namely the set of all elements of the domain that satisfy the predicate. Conversely, any set S defines a predicate P (x): x ∈ S. Today we discuss an extension of this correspondence to predicates on two variables. Consider a predicate P (x, y) where x ∈ D 1 and y ∈ D 2 (recall tha...

The gamma-carboxyglutamic acid (Gla) domain of blood coagulation factors is responsible for Ca2+-dependent phospholipid membrane binding. Factor X-binding protein (X-bp), an anticoagulant protein from snake venom, specifically binds to the Gla domain of factor X. The crystal structure of X-bp in complex with the Gla domain peptide of factor X at 2.3-A resolution showed that the anticoagulation ...

The integrin X 2 (CD11c CD18, p150,95) binds ligands through the I domain of the X subunit. Ligands include the complement factor fragment iC3b, a key component in the innate immune defense, which, together with the expression of X 2 on dendritic cells and on other leukocytes, suggests a role in the immune response. We now report the structure of the X I domain resolved at 1.65 Å by x-ray cryst...