Epilepsy has become second most common neurological disorder affecting 70 million people worldwide. Several shortcomings appeared with the use of conventional antiepileptic drugs (AEDs) like, inadequate seizure control, side effects, cost, potentiation of epilepsy-induced co-morbidities, etc., which limit their use as comprehensive therapy. Phytoflavonoids in this regard have been observed to b...

the goal of this study was to investigate the common clinical chemistry and distribution of xanthine oxidase (xo) in selected tissues of a mouse model of menopause. twenty four nmri female mice were divided into three groups: normal control (nc), and ovariectomized (ovx) groups and an estrogen-treated ovariectomized (ovx+e) group which received subcutaneous injection of estradiol benzoate (2 mg...

The effects of petroleum products (kerosene, diesel, engine oil and petrol) treatment of soil at various sublethal concentrations (0.0%, 0.1%, 0.25%, 0.5%, 1.0%, 1.5% and 2.0%) on oxidative stress markers (lipid peroxidation, superoxide dismutase activity, catalase activity and xanthine oxidase) were studied in cowpea and maize seedlings. The results indicated that the petroleum products caused...

The aim of this study was to investigate the antioxidant properties of the ethanol extract of the flower of Camellia japonica (Camellia extract). Camellia extract exhibited 1,1-diphenyl-2-picrylhydrazyl radical and intracellular reactive oxygen species (ROS) scavenging activity in human HaCaT keratinocytes. In addition, Camellia extract scavenged superoxide anion generated by xanthine/xanthine ...

The present study was carried out to investigate the antioxidant, cytoprotective and antibacterial effects of aqueous and hydroalcoholic extracts of Hippophae rhamnoides L. (Sea buckthorn) (SBT) leaves by using various in vitro systems and analysis of marker compounds by reverse phase-high performance liquid chromatography (RP-HPLC). The chemical composition of the leaf extracts was quantified ...

Fifteen phenolic compounds, including three caffeoyl derivatives, four gallotannins, three ellagitannins and five flavonoids, were isolated from an 80% MeOH extract of the leaves of Corylopsis coreana Uyeki (Korean winter hazel; CL). The anti-oxidative activities [1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity and xanthine oxidase superoxide scavenging activities (NBT)] and th...

Antioxidant and pro-oxidant systems were studied in overwintering larvae of two cold-hardy gall insect species, the freeze-tolerant fly Eurosta solidaginis and the freeze-avoiding moth Epiblema scudderiana. An increase in the levels of the oxidized form of glutathione suggested slight oxidative stress in both species during the winter. Freeze-tolerant Eurosta solidaginis larvae generally had de...

2-Styrylchromones (2-SC) are a chemical family of oxygen heterocyclic compounds, vinylogues of flavones (2-phenylchromones), whose occurrence in nature has been reported. Recently, several 2-SC derivatives were demonstrated to have antioxidant properties, namely, xanthine oxidase inhibition, hepatoprotection against pro-oxidant agents in cellular and non-cellular systems and scavenging activity...

Continuously performing heavy activities will damage tissues and cells cause oxidative stress. Fortunately, this can be reduced by giving antioxidants to reduce free radicals. This study uses the forced swimming test model determine effect of Javanese ginseng root extract on superoxide dismutase levels in male white Sprague Dawley rats. The samples were 30 rats divided into five groups: negativ...

1. The catalytic properties of xanthine oxidase in bovine milk (EC 1.2.3.2) are dependent on the state of the enzyme, i.e. whether free or bound to the fat-globule membrane. Oxidase activity of the membrane-bound enzyme towards NADH is enhanced relative to that towards xanthine. This reflects a change in the relative K(m) values and enables the ratio of xanthine to NADH oxidase activities (X/N)...