Our previous study reported the favorable short-term outcome and good tolerance of integrating oxaliplatin into capecitabine-based (XELOX regimen) preoperative chemoradiotherapy (CRT) for locally advanced rectal cancer (LARC). The present study reported the long-term oncological outcome of this phase II study. A total of 47 patients with rectal adenocarcinoma (stage II or III) were enrolled and...

1. Bevacizumab Not Helpful for Stage III Colorectal Cancer 2. Screening for KRAS and BRAF Mutations 3. Aspirin May Help Older Colon Cancer Patients Live Longer 4. Hypertension Means Better Survival When Treated with Avastin 5. Reduced Risk of Colorectal Cancer With Use of Oral Bisphosphonates 6. Xelox and Avastin Followed by Single Agent Avastin as Maintenance Therapy in First Line Treatment of...

Capecitabine (Xeloda) offers a unique mode of action. The drug is currently being combined with other active agents in the treatment of advanced breast cancer. The recent demonstration of improved disease-free and overall survival with the capecitabine/docetaxel (Taxotere) combination, for example, has encouraged investigation of additional capecitabine/taxane regimens and schedules. A unique a...

BACKGROUND The aim of this study was to compare the efficacy of two neoadjuvant chemotherapies (FLEEOX and XELOX) with different routes of administration for unresectable gastric cancer. METHODS A total of 85 patients with unresectable gastric cancer hospitalized from January 2007 to December 2009 received neoadjuvant chemotherapy. The FLEEOX group (48 patients) received the FLEEOX regimen(fl...

Capecitabine is a chemotherapeutic agent of the fluoropyrimidine family, indicated in metastatic colorectal cancer and advanced breast cancer. Its main cutaneous adverse effect is hand-foot syndrome (HFS); cases of skin hyperpigmentation, nail changes, and alterations of the mucosas secondary to this drug have also been reported. Capecitabine is converted to 5-fluorouracil by the enzyme thymidi...

Colorectal cancer is one of the leading causes of cancer-related death worldwide, with almost 20% of all patients presenting with metastatic disease at the time of their diagnosis. The treatment regimens and options of metastatic colorectal cancer have significantly changed in the last 10 years, leading to an improvement of response rates to about 50%, progression-free survival of about 10 mont...

Either alone or in combination with other antineoplastics, fluorouracil (5-FU) has been the mainstay of treatment of gastrointestinal, breast, and head and neck cancers for the past 40 years. Numerous active 5-FU schedules are in clinical use, but erratic oral bioavailability has historically mandated intravenous administration. Recently, two methods have been used to overcome the poor oral bio...