We studied the adrenosuppressive effect of antiandrogen TZP-4238 and its metabolites. The binding affinity for the corticosteroid receptor using rat hepatic cytosol was in the order 11-OH TZP-4238 > 11, 15-(OH)2 TZP-4238 >> TZP-4238 > or = 15-OH TZP-4238 > 11-keto TZP-4238. Male beagle dogs aged 1-6 years were randomly divided into TZP-4238 (0.05, 0.5mg/kg) treatment groups and CMA (0.5mg/kg) t...

Abstract Purpose of Review Yttria-stabilized zirconium dioxide, 3 mol% Y-TZP (zirconia, 3Y-TZP) was introduced as a prosthetic material to provide metal-free, tooth-colored, and durable option for the patients. However, its optical properties are not ideal. This review describes different strategies increase translucency zirconia summarizes current knowledge translucent fixed prosthodontic appl...

In recent years, 3 mol% yttria stabilized tetragonal zirconia polycrystals (3Y-TZP) doped with copper oxide has obtained increasing interest due to its enhanced superplasticity and good potential in tribological applications. In this work, the effect of addition of small amounts (0.8 mol%) of CuO on the sintering behaviour of 3Y-TZP was studied using a dilatometer and high temperature X-ray dif...

Bars of Y-TZP ceramic for dental restorations were subjected to hydrothermal degradation via in vitro exposure to water steam at 140°C for 7 days. X-ray diffraction, atomic force microscopy and scanning electron microscopy techniques were applied to observe and quantify the tetragonal-monoclinic (t-m) phase transformation associated with the process. Nanoindentation was used to assess the ceram...

OBJECTIVES To evaluate the bonding of resin-cement to yttria-stabilized tetragonal zirconia polycrystal (Y-TZP) via silica coating followed by silanization, and three one-bottle universal adhesives, with or without prior conditioning using a zirconia primer. METHODS Y-TZP specimens (n=160) were conditioned by tribochemical silica coating and silanization (CS), or alumina sandblasting with one...

The purpose of this study was to evaluate the effect of different surface treatments of yttria-stabilized tetragonal zirconia (Y-TZP) on bond strength durability and marginal discrepancies. For adhesion testing, 144 specimens of VITA In-Ceram YZ ceramic for InLab were obtained (5.25×3.75×4.5 mm) and divided into six groups (n=24) according to the surface treatment: 1) Control (CRTL): untreated;...