Downlo PIM family of serine threonine protein kinases plays an important role in regulating both the growth and rmation of malignant cells. However, in a cell line–dependent manner, overexpression of PIM1 can t cell and tumor growth. In 22Rv1 human prostate cells, but not in Du145 or RWPE-2, PIM1 oversion was associated with marked increases in cellular senescence, as shown by changes in the le...

acrjourna h levels of the critical p53 inhibitor Mdm4 is common in tumors that retain a wild-type p53 allele, ting that Mdm4 overexpression is an important mechanism for p53 inactivation during tumorigenesis. t this hypothesis in vivo, we generated transgenic mice with widespread expression of Mdm4. Two ndent lines of transgenic mice, Mdm4 and Mdm4, developed spontaneous tumors, the most prevf ...

English teachers are frequently asked to help colleagues prepare presentations for internationalconferences. Sometimes this assistance takes the form of a language course or tutorials focusingon the spoken language. Contact time is short but the participants are highly motivated. Whattype of pronunciation work will provide the greatest payoff in terms of successfully beingunders...

This report summarizes the proceedings of the 6th and 7th workshops of the Genomic Standards Consortium (GSC), held back-to-back in 2008. GSC 6 focused on furthering the activities of GSC working groups, GSC 7 focused on outreach to the wider community. GSC 6 was held October 10-14, 2008 at the European Bioinformatics Institute, Cambridge, United Kingdom and included a two-day workshop focused ...

A comparison of the product yield, total phenolics, total flavonoids, and antioxidant properties was done in different leafy vegetables/herbs (basil, chard, parsley, and red kale) and fruit crops (bell pepper, cherry tomatoes, cucumber, and squash) grown in aeroponic growing systems (AG) and in the field (FG). An average increase of about 19%, 8%, 65%, 21%, 53%, 35%, 7%, and 50% in the yield wa...

The octyl alcohol, DL-2-ethyl-fl-hexanol, is used industrially as a solvent and, in the form of the ester, di-2-ethylhexyl phthalate, as a plasticizer. According to Shaffer, Carpenter & Smyth (1945) this ester is saponified in rats and rabbits, phthalic acid being excreted and there being also an increase in the short-chain fatty acids in the urine. After feeding the DL-alcohol to rabbits, Akiy...

grinoides ranges from the Canary Islands eastwards across some areas of North Africa, the Middle East and some parts of central Asia (Fergusson-Lees and Christie, 2002). It has characteristic plumage patterns and morphometric differences with respect to the rest of peregrine subspecies, but genetic variation is quite low in the peregrinus/pelegrinoides group, and it could be treated as a subspe...

53 The Rockefeller University Press $30.00 J. Cell Biol. Vol. 216 No. 1 53–63 https://doi.org/10.1083/jcb.20161001