ABCA12: adenosine triphosphate binding cassette A12 HI: harlequin ichthyosis NICU: neonatal intensive care unit INTRODUCTION Harlequin ichthyosis (HI) is a rare autosomal recessive congenital ichthyosis associated with mutations in the keratinocyte lipid transporter adenosine triphosphate binding cassette A12 (ABCA12), leading to disruption in lipid and protease transport into lamellar granules...

We investigate the role of externalities in tax evasion arising from congestion of the auditing resources available to local tax authorities. The empirical analysis employs a novel method due to Graham (2008) that mitigates most of the problems that surround the identification of endogenous social effects [Manski (1993)]. Identification exploits the information contained in the variance of conc...

We construct a measure of gubernatorial candidates’ personal appeal by showing 10-second, silent video clips of unfamiliar gubernatorial debates to a group of experimental participants and asking them to predict the election outcomes. The participants’ predictions explain more than 20 percent of the variation in the actual two-party vote share across the 58 elections in our study, and their imp...

Abstract BACKGROUND We recently reported favorable safety, promising clinical efficacy and immunohistochemical indicators of response after radiotherapy (RT) plus escalating doses the CXCL12-neutralizing RNA-Spiegelmer olaptesed pegol (NOX-A12) for glioblastoma in German multicenter phase 1/2 GLORIA trial (NCT04121455). Here, we report outcomes RT dual inhibition vasculogenesis angiogenesis (be...

Marine oil spill detection is vital for strengthening the emergency commands of accidents and repairing marine environment after a disaster. Polarimetric Synthetic Aperture Radar (Pol-SAR) can obtain abundant information targets by measuring their complex scattering matrices, which conducive to analyze interpret mechanism slicks, look-alikes, seawater realize extraction slicks. The polarimetric...

Purpose: To compare non-cycloplegic refraction measurements of two photoscreeners and the hand-held autorefractometer with cycloplegic in patients attention deficit hyperactivity disorder (ADHD).
 Meterials methods: This cross-sectional, comparative study consisted 53 children who were newly diagnosed ADHD. We compared spherical, cylindrical, cylindrical axis spherical equivalent (SE) Plus...

Let A = ( A11 A12 A21 A22 ) ∈ Mn, where A11 ∈ Mm with m ≤ n/2, be such that the numerical range of A lies in the set {eiφz ∈ C : |=z| ≤ (<z) tanα}, for some φ ∈ [0, 2π) and α ∈ [0, π/2). We obtain the optimal containment region for the generalized eigenvalue λ satisfying λ ( A11 0 0 A22 ) x = ( 0 A12 A21 0 ) x for some nonzero x ∈ C, and the optimal eigenvalue containment region of the matrix I...

A filamentous phage library displaying a vast repertoire of synthetic single chain fragment variable (scFv) antibody fragments was subjected to affinity selection on purified bluetongue virus (BTV) particles. After four rounds of selection and amplification, 73 out of a total of 90 fusion phage clones tested were found to bind to purified BTV in ELISA. One of these, the clone producing the high...