PURPOSE In this study we have examined the effects of zoledronic acid (ZA), a new-generation bisphosphonate, on prostate cancer (CaP) cells in vitro, and on both osteoblastic and osteolytic CaP metastases in animal models. EXPERIMENTAL DESIGN In vitro, CaP cells were treated with ZA, and the effects on proliferation, cell cycle, and apoptosis were determined. In vivo, PC-3, and LuCaP 23.1 s.c...

Covalently conjugating multiple copies of the drug zanamivir (ZA; the active ingredient in Relenza) via a flexible linker to poly-l-glutamine (PGN) enhances the anti-influenza virus activity by orders of magnitude. In this study, we investigated the mechanisms of this phenomenon. Like ZA itself, the PGN-attached drug (PGN-ZA) binds specifically to viral neuraminidase and inhibits both its enzym...

SADRŽAJ Umesto predgovora: Iz izveštaja “EFT – energetska mafija” ...........................................................................1 Umesto uvoda: Vladimir Popović Beba o tajkunskoj državi .............................................................................3 21-22.02.2004 ‘Danas’.....................................................................................................

In the paper we apply progressive waveletcorrelation using Fourier methods to locate objects in aJPEG image. The image is searched step by step. Thesearching consists of three incremental steps, each ofwhich quadruples the number of correlation points. Theprocess can be halted at any stage if the intermediateresults indicate that the correlation will not result in am...

In this paper we present CroNER, a named entity recognition and classification system for Croatian language based on supervised sequence labeling with conditional random fields (CRF). We use a rich set of lexical and gazetteer-based features and different methods for enforcing document-level label consistency. Extensive evaluation shows that our method achieves state-of-the-art results (MUC F1 ...

BACKGROUND Adjuvant zoledronic acid (za) appears to improve disease-free survival (dfs) in women with early-stage breast cancer and low levels of estrogen (lle) because of induced or natural menopause. Characterizing the cost-utility (cu) of this therapy could help to determine its role in clinical practice. METHODS Using the perspective of the Canadian health care system, we examined the cu ...

Zoledronic acid (ZA) is a biphosphonate used for osteoporosis treatment and also proved to be effective to reduce the pain induced by bone metastases when used as adjuvant therapy in solid cancers. However, it has been recently proposed that ZA could have direct anti-tumour effects, although the molecular mechanism is unknown. We herein unravel a novel anti-tumour activity of ZA in prostate can...

PURPOSE The addition of bisphosphonates to adjuvant therapy improves survival in postmenopausal breast cancer (BC) patients. We report a meta-analysis of four randomised trials of neoadjuvant chemotherapy (CT) +/- zoledronic acid (ZA) in stage II/III BC to investigate the potential for enhancing the pathological response. METHODS Individual patient data from four prospective randomised clinic...

Prema definiciji Svetske zdravstvene organizacije farmakovigilanca je nauka ili skup aktivnosti povezanih sa detekcijom, procenom, razumevanjem i prevencijom neželjenih efekata ili bilo kojih drugih problema povezanih sa upotrebom lekova . Pod farmakovigilancom se, generalno, smatralo postmarketinško praćenje neželjenih efekata lekova u četvrtoj fazi kliničkih istraživanja lekova . Međutim, sa ...

Republička stručna komisija za nadzor nad bolničkim infekcijama Ministarstva zdravlja Republike Srbije je, na osnovu najnovijih preporuka Svetske zdravstvene organizacije , inovirala već postojeće preporuke za prevenciju širenja ptičjeg gripa u zdravstvenim ustanovama 2 koje su bile pripremljene prema postojećim preporukama Svetske zdravstvene organizacije 3 i Centara za kontrolu zaraznih boles...