The intracellular bioavailability of lead (Pb) at low dosage levels in major target organs such as the kidney and brain appears to be largely determined by complexation with a group of low molecular weight proteins. These proteins are rich in aspartic and glutamic dicarboxyl amino acids. The proteins are chemically similar but not identical across all species examined to date and the brain prot...

chloride or cadmium nitrate. However, the complexation was secondary in relation to ninhydrin-amino acid reaction [4]. At the end of the 1990’s, a new component named 1,2-IND (1,2-indanedione) was applied, which reacted with amino acids and with DFO, whereby the reaction product exhibited fluorescent properties [5, 6]. The follow-up scientific activity within this scope was focused on the optim...

A multi-histidinic peptide and its minimal models have been investigated for Zn(ii) binding. We have used NMR spectroscopy to probe the binding of zinc to the three repeats (T(1)R(2)S(3)R(4)S(5)H(6)T(7)S(8)E(9)G(10))(3) and to its mono-histidinic minimal models, the 9- and 10-aminoacid fragment. (1)H-(1)H TOCSY, (1)H-(13)C HSQC, (1)H-(1)H NOESY and (1)H-(1)H ROESY multidimensional NMR technique...

The main aim of this study was the analysis of the interaction between humic acids (HAs) from different soils and Zn(II) ions at wide concentration ranges and at two different pHs, 5 and 7, by using fluorescence and FTIR spectroscopy, as well as potentiometric measurements. The presence of a few areas of HAs structures responsible for Zn(II) complexing was revealed. Complexation at α-sites (low...

The highly ordered mesoporous silica media, SBA-15, was synthesized and incorporated with iron, aluminum, and zinc oxides using an incipientwetness impregnation technique. Adsorption capacities and kinetics of metal-impregnated SBA-15 were compared with activated alumina which is widely used for arsenic removal. Media impregnated with 10% of aluminum by weight (designated to Al10SBA-15) had 1.9...

Selective complexation of metal ions represents a powerful tool for the development versatile supramolecular architectures. While research in field molecular devices and machinery is sophisticated, selective formation complexes not prevalent polymer chemistry. Thus, implementation orthogonal binding concepts into polymeric matrix presented. In this context, an end-functionalized poly(N-isopropy...

Fluorescent sensor molecules were synthesized by conjugation of iminodiacetamide derivatives with fluorescent moieties of different structures and their UV-visible and fluorescent properties were characterized in acetonitrile solvent. The fluorescent measurements revealed that the N-(2-naphthyl) and N-phenyl derivatives exhibit a distinct zinc ion-selectivity over alkali and alkaline earth meta...

α,α-Dimethyl-4-[1-hydroxy-4-[4-(hydroxydiphenylmethyl)-1-piperidinyl]butyl]benzene acetic acid generically known as fexofenadine or carboxyterfenadine is a second generation H1-receptor antagonist, much widely used due to its non-sedative effects. Metal complexes of fexofenadine with various essential and trace elements of biological interest, have been synthesized and characterized by FT-IR, 1...

The antimicrobial activity of some novel ascorbic acid-metal complexes [bisascorbate complexes of copper (II), zinc(II), manganese (11), iron (111), cobalt(II), lead(II) and cadmium(II)] was investigated. Four standard strains of bacterial species - Staphylococcus aureus, Escherichia coli, Bacillus subtilis and Klebsiella pneumonia and four fungal species - Trichophyton sp. Penicillium sp....