نتایج جستجو برای: zipper
تعداد نتایج: 3644 فیلتر نتایج به سال:
The zipper is a well known design pattern for providing a cursor-like interface to a data structure. However, the classic treatise by Huet only scratches the surface of some of its potential applications. In this paper we take inspiration from Huet, and describe a library suitable as an underpinning for structured editors. We consider a zipper structure that is suitable for traversing heterogen...
when structures are subjected to strong ground motion excitations, structural elements may be prone to yielding, and consequently experience significant levels of inelastic behavior. the effects of inelastic behavior on the distribution of peak floor loads are not explicitly accounted for in current seismic code procedures. during recent years, many studies have been conducted to develop new de...
Pentagonal conjugates of tryptophane zipper-forming peptide (CKTWTWTE) with a pentaazacyclopentadecane core (Pentagonal-Gly-Trpzip and Pentagonal-Ala-Trpzip) were synthesized and their self-assembling behaviors were investigated in water. Pentagonal-Gly-Trpzip self-assembled into nanofibers with the width of about 5 nm in neutral water (pH 7) via formation of tryptophane zipper, which irreversi...
Conformational adaptation between antigen and antibody can modulate the antibody specificity. The phenomenon has often been proposed to result from an 'induced fit', which implies that the binding reaction induces a conformational change in the antigen and the antibody. Thus, an 'induced fit' requires initial complex formation followed by a conformational change in the complex. However, an anti...
When structures are subjected to strong ground motion excitations, structural elements may be prone to yielding, and consequently experience significant levels of inelastic behavior. The effects of inelastic behavior on the distribution of peak floor loads are not explicitly accounted for in current seismic code procedures. During recent years, many studies have been conducted to develop new de...
The KP element can repress P element mobility in Drosophila melanogaster. Three mutant KP elements were made that had either two amino acid substitutions or a single amino acid deletion in the putative leucine zipper domain found in the KP polypeptide. Each KP element was expressed from the actin 5C proximal promoter. The wild-type control construct strongly repressed P element mobility, measur...
MicroRNAs (miRNAs) loss-of-function phenotypes are mainly induced by chemically modified antisense oligonucleotides. Here we develop an alternative inhibitor for miRNAs, termed 'small RNA zipper'. It is designed to connect miRNA molecules end to end, forming a DNA-RNA duplex through a complementary interaction with high affinity, high specificity and high stability. Two miRNAs, miR-221 and miR-...
The dimerization specificity of the bZIP transcription factors resides in the leucine zipper region. It is commonly assumed that electrostatic interactions between oppositely charged amino acid residues on different helices of the leucine zipper contribute favorably to dimerization specificity. Crystal structures of the GCN4 leucine zipper contain interhelical salt bridges between Glu20 and Lys...
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