how to cite this article: taghdiri mm, bakhshandeh bali mk, karimzadeh p, ashrafi mr, tonekaboni sh, ghofrani m. comparative efficacy of zonisamide and pregabalin as an adjunctive therapy in children with refractory epilepsy. iran j child neurol. 2015 winter;9(1):49-55. abstract objective approximately one third of epileptic children are resistant to anticonvulsant drugs. this study evaluates t...

BACKGROUND Migraine is one of the most debilitating medical conditions and has a high socioeconomic burden. As conventional therapeutic methods do not entirely alleviate the symptoms, new alternatives are being considered. OBJECTIVES This study evaluates the efficacy and safety of zonisamide compared with sodium valproate in the management of migraine headaches. PATIENTS AND METHODS In the ...

A selective and sensitive liquid chromatographic method has been developed for simultaneous determination of zonisamide and its four related substances in pharmaceutical dosage forms. The assay involved an isocratic elution in perfectsil Target C18 column using a mobile phase composition of disodium hydrogen phosphate buffer, acetonitrile and methanol (650:150:200 v/v, pH adjusted to 3±0.05) wi...