Isothiocyanates are the most intensively studied breakdown products of glucosinolates from Brassica plants and well recognized for their pleiotropic effects against cancer but also for their genotoxic potential. However, knowledge about the bioactivity of glucosinolate-borne nitriles in foods is very poor. As determined by GC-MS, broccoli glucosinolates mainly degrade to nitriles as breakdown p...

Functionalized alkenyl chalcogenides (S, Se and Te) have great potential in organic synthesis, since they are valuable intermediates for the selective preparation of several organic compounds.1-7 The synthesis of vinylic chalcogenides has therefore attracted the attention of several research groups, and many novel methods for their preparation have been proposed in the last years.1-7 We describ...

An efficient methodology to oxidize benzylic and cinnamyl alcohols to their corresponding nitriles in excellent yields has been developed. This methodology employs DDQ as an oxidant and TMSN(3) as a source of nitrogen in the presence of a catalytic amount of Cu(ClO(4))(2)·6H(2)O.

3.1. Overview 2807 3.2. Chiral Aluminum(III) Complexes as a Catalyst 2808 3.2.1. Aluminum(III)-Salen-Based Catalysts 2808 3.2.2. Aluminum(III)-Binaphthol-Based Catalysts 2810 3.3. Chiral Titanium(IV) Complexes as a Catalyst 2814 3.3.1. Titanium(IV)-Peptide-Based Catalysts 2814 3.3.2. Titanium(IV)-Diol-Based Catalysts 2817 3.4. Chiral Zirconium(IV) Complexes as a Catalyst 2818 3.4.1. The Catalyt...

Abstract The selective α‐deuteration of α,β‐unsaturated nitriles using the strong base t BuOK or a metal‐ligand cooperative Ru pincer catalyst is described. With D 2 O as deuterium source and glyme solvent at 70 °C, an efficient for deuteration α‐C( sp ) position cinnamonitriles, providing access to broad range deuterated derivatives in good excellent yields with very high levels incorporation....

Next-generation DNA sequencing (NGS) has made it feasible to sequence large number of microbial genomes and advancements in computational biology have opened enormous opportunities to mine genome sequence data for novel genes and enzymes or their sources. In the present communication in silico mining of microbial genomes has been carried out to find novel sources of nitrilases. The sequences se...

In previous papers from this laboratory (1, 2) it has been reported that a-amino acids undergo a quantitative decarboxylation.in aqueous solution when treated with N-bromosuccinimide. Under the conditions used\ (a temperature of 30” and a pH of 3 to 5), the reaction was complete in 30 minutes. Anomalies in behavior were observed with glycine and /3-alanine. The consumption of N-bromosuccinimide...

By applying a diversity oriented synthesis strategy for the search of new antagonists of the thrombin receptor PAR1, a series of peptide-based ureas and thioureas, including analogues of the PAR1 reference antagonist RWJ-58259, has been designed and synthesized. The general synthetic scheme involves reduction of basic amino acid-derived amino nitriles by hydrogen transfer from hydrazine monohyd...