OBJECTIVE To establish an algorithm for first-trimester combined screening for trisomy 21 with biochemical testing from 7 to 14 weeks' gestation and ultrasound testing at 11-13 weeks. METHODS This was a multicenter study of 886 pregnancies with trisomy 21 and 222 475 unaffected pregnancies with measurements of free β-human chorionic gonadotropin (β-hCG) and pregnancy-associated plasma protein...

in circumstances such as in vitro fertilization (ivf) or in patients with luteal phase defect, one needs to ensure the establishment of pregnancy as soon as possible. at the same time, a question arises: how can a physician make sure that the β-hcg is of an endogenous source and not the residue of the prescribed drugs (hcg)? in this article we have studied the elimination time of 1m injection o...

placenta increta, a rare complication of pregnancy, is associated with significant postpartum hemorrhage often requiring emergency hysterectomy. we report a case of conservative management, with a combination of parenteral methotrexate, serial ultrasound and β-hcg assessment. serum β-hcg levels were undetectable after 8 weeks of therapy. a scan at 6 months showed complete involution of the uter...

The objective is to report the case of a 36 year-old female with a primary mediastinal germ cell tumor mimicking an ectopic pregnancy. The patient under birth control pill presented, at seven weeks of amenorrhea, a β-human chorionic gonadotropin (β-hCG) level of 850 UI and uterine vacuity with left lateral uterine heterogeneous mass but no bleeding and no pain. She received left adnexectomy, ut...

OBJECTIVE To investigate whether maternal serum pregnancy associated plasma protein-A (PAPP-A), total β human chorionic gonadotropin (hCG) levels and nuchal translucency (NT) measurements differ in women with pre-gestational diabetes mellitus (PGDM) compared to non-diabetic controls and to assess whether correction factors are needed for diabetic women in calculation of aneuploidy risks. STUD...

In this study, we aimed to investigate whether there was an association between fetal nuchal translucency (NT) and the serum markers plasma protein-A (PAPP-A) free beta-human chorionic gonadotropin (β-hCG) measured by first-trimester screening test, as well birth weight hypertension. 454 pregnant women who had undergone test for Down syndrome were included in study. All measurements values of N...

OBJECTIVE To determine if combinations of maternal characteristics and measurements of parameters used in screening for aneuploidies at 11-13 weeks provide significant prediction of macrosomia. METHOD Maternal characteristics, fetal nuchal translucency (NT), free β-human chorionic gonadotrophin (β-hCG) and pregnancy-associated plasma protein-A (PAPP-A) were recorded at 11(+0)-13(+6) weeks in ...

Background: Premature Rupture of Membranes (PROM) is common in obstetrics and management such patients depends on whether the rupture has occurred or not. With membranes ruptured fetus deprived protection provided within amniotic cavity. Beta-Human chorionic gonadotrophin (β-HCG) a hormone present high concentration fluid as well blood urine mother studied possible predictor preterm labour mark...