Background: The genus Eryngium, Apiaceae is widely distributed in the world and used traditional medicine for different therapeutic purposes. Eryngium thyrsoideum was investigated due to a lack of phytochemical studies on probable bioactivities its compounds. Methods: aerial parts plant were extracted using n-hexane, dichloromethane, methanol (MeOH) by soxhlet method. MeOH extract exposed C18 S...

The paroxysm of hematin intoxication in the rabbit undoubtedly presents many features of striking similarity to the paroxysm of human malaria; still one must hesitate to apply such results unreservedly in an attempt to identify the causative agent of the malarial paroxysm. When, in addition to the character of the paroxysm, we consider the sequence of events in the two instances, the analogy be...

Hematin catalysis of unsaturated lipide oxidation is probably a primary reaction in many types of pathological unsaturated fat oxidation in viva (l-3) and in the spoilage of frozen meat products by oxidative fat rancidity (4). Some of the properties of hematin catalysis have been described (4-8), but knowledge of the reaction mechanism and the reaction products is relatively meager. The catalyt...

The relationship of rabbit Cx-reactive protein (CxRP) and the enzymatic activity of hepatic and kidney catalases in rabbits following i.v. hematin administration has been examined sequentially. The early increases in rab bit liver and kidney catalatic activities were accompanied by the corresponding decreases in ßCxRP and an early appearance of 7 CxRP after hematin administration. Immunoelectr...

Hematin is clincally useful in the treatment of acute intermittent porphyria. Recently, hematin-induced coagulopathy has been reported. and a patient we treated bled during hematin therapy. On 3 separate occasions. infusions of hematin (4 mg/kg) induced thrombocytopenia, prolongation of the prothrombin time, partial thromboplastin time. Reptilase time and apparent decreases in fibrinogen and in...

Heme arginate infusions blunt the symptoms of patients with acute intermittent porphyria without evidence of the vascular or thrombotic side effects reported for hematin. To provide a rationale for heme arginate's safety, the present study examined the effects of various ferriporphyrins to sensitize human endothelial cells to free radical injury and to induce heme oxygenase and ferritin express...

Hematin catalysis of unsaturated lipide oxidation is probably a primary reaction in many types of pathological unsaturated fat oxidation in viva (l-3) and in the spoilage of frozen meat products by oxidative fat rancidity (4). Some of the properties of hematin catalysis have been described (4-8), but knowledge of the reaction mechanism and the reaction products is relatively meager. The catalyt...

The relationship of rabbit Cx-reactive protein (CxRP) and the enzymatic activity of hepatic and kidney catalases in rabbits following i.v. hematin administration has been examined sequentially. The early increases in rab bit liver and kidney catalatic activities were accompanied by the corresponding decreases in ßCxRP and an early appearance of 7 CxRP after hematin administration. Immunoelectr...