نتایج جستجو برای: β peptide
تعداد نتایج: 328916 فیلتر نتایج به سال:
introduction: evidence suggests that neuronal apoptosis in neurodegenerative diseases is correlated with inflammatory reactions. the beneficial or detrimental role of apoptosis in neuroinflammation is unclear. elucidating this question may be helpful in management of neurodegenerative diseases. since tnf-α is able to induce apoptosis as well as increased viability of the cells by activation of ...
Due to the non-polar nature of carbon nanotubes, their use in aqueous environments is limited. Therefore, auxiliary solvents such as dimethyl sulfoxide are used to study the interactions between the amyloid-β peptide and carbon nanotubes. In this work, the interaction of Aβ (1-42), the most effective peptide in the development of Alzheimer's disease, with the carbon nanotube was performed using...
SB056 is a novel semi-synthetic antimicrobial peptide with a dimeric dendrimer scaffold. Active against both Gram-negative and -positive bacteria, its mechanism has been attributed to a disruption of bacterial membranes. The branched peptide was shown to assume a β-stranded conformation in a lipidic environment. Here, we report on a rational modification of the original, empirically derived lin...
OBJECTIVE Maintenance of endogenous pancreatic β-cell function could be an important goal in the management of type 1 diabetes. However, the impact of stimulated C-peptide level on overall glycemic control is unknown. The relationship between C-peptide and parameters of glucose control was therefore characterized in a cohort with rapidly changing β-cell function following islet transplantation....
Introduction: Evidence suggests that neuronal apoptosis in neurodegenerative diseases is correlated with inflammatory reactions. The beneficial or detrimental role of apoptosis in neuroinflammation is unclear. Elucidating this question may be helpful in management of neurodegenerative diseases. Since TNF-α is able to induce apoptosis as well as increased viability of the cells by activation ...
RATIONALE The prevalence of Alzheimer's disease is increased in people with Down syndrome. The pathology appears much earlier than in the general population, suggesting a predisposition to develop Alzheimer's disease. Down syndrome results from trisomy of human chromosome 21, leading to overexpression of possible Alzheimer's disease candidate genes, such as amyloid precursor protein gene. To be...
High-resolution structures of oligomers formed by the β-amyloid peptide Aβ are needed to understand the molecular basis of Alzheimer's disease and develop therapies. This paper presents the X-ray crystallographic structures of oligomers formed by a 20-residue peptide segment derived from Aβ. The development of a peptide in which Aβ17-36 is stabilized as a β-hairpin is described, and the X-ray c...
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