Background: This work aimed at studying the protective effect of melatonin (MLT) against cypermethrin or γ-radiation induced testicular damage. Material and Methods: Thirty six Male rats were randomly divided into 6 groups.  Control group, group treated with MLT (10 mg/Kg b. wt.), group administered cypermethrin (25 mg/ kg. b. wt.), group 4 was exposed to fractionated whole body γ-radiation (th...

PURPOSE The purpose of the present study was to assess the biological effects of TNF-alpha in Caco-2 well-differentiated colon adenocarcinoma cells and to determine radiation sensitivity in order to develop TNF-alpha into a cancer therapeutic agent. MATERIALS AND METHODS A cell viability test was conducted via a colorimetric and colony forming assay after 1 day and 3 days of incubation with T...

The objective was to study the effects of one time exposure to small clinically relevant dose of 60 cobaltgamma ( 60 Co-γ) radiation on histological changes in brain and consequent effects on conditioned taste aversion (CTA) in experimental rats. Rats were total body 60 Co-γ-irradiated in GammaCell; CTA to saccharin was assessed in terms of saccharin preference ratio (SPR) using a standardized ...

OBJECTIVE Osteosarcoma (OS) is the most common primary malignant bone tumour in children and adolescents. Despite aggressive therapy, survival outcomes remain unsatisfactory, especially for patients with metastatic disease or patients with a poor chemotherapy response. Previous study founds inosine 5'-monophosphate dehydrogenase type II (IMPDH2) was an independent prognostic factor and observed...

background: a new biological dosimeter based on methemoglobin level was developed in this study. materials and methods: methemoglobin level in erythrocytes from mice subjected to γ rays from a 60co source was detected using the methemoglobin kit. the dose range was from 0.5 to 8 gy and the dose rate was 0.5 gy/min. results: the results demonstrate that methemoglobin level increases with increas...

Adequate oxygen stress induced by low-dose irradiation activates biodefense system, such as induction of the synthesis of superoxide dismutase (SOD) and glutathione peroxidase. We studied the possibility for alleviation of oxidative damage, such as diabetes and nonalcoholic liver disease. Results show that low-dose γ-irradiation increases SOD activity and protects against alloxan diabetes. Prio...

BACKGROUND The aim of the study was to clarify the effect of p53 status of tumor cells on radiosensitivity of solid tumors following accelerated carbon-ion beam irradiation compared with γ-rays or reactor neutron beams, referring to the response of intratumor quiescent (Q) cells. METHODS Human head and neck squamous cell carcinoma cells transfected with mutant TP53 (SAS/mp53) or with neo vect...

Echinococcosis is a serious parasitic disease caused by Echinococcus tapeworms. Protoscoleces are sometimes released during surgical treatment for hydatid cysts, causing the recurrence of echinococcosis. Protoscoleces may be susceptible to radiation therapy. In this study Echinococcus protoscoleces were cultured in vitro and then divided into four different γ-ray irradiation dose groups (10 Gy,...