-Amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA)-type glutamate receptors (AMPARs) mediate excitatory neurotransmission at neuronal synapses, and their regulated localization plays a role in synaptic plasticity. In Caenorhabditis elegans, the PDZ and PTB domain-containing protein LIN-10 is required both for the synaptic localization of the AMPAR subunit GLR-1 and for vulval fate indu...

The Generalized LR (GLR) parsing algorithm is attractive for use in parsing programming languages because it is asymptotically efficient for typical grammars, and can parse with any context-free grammar, including ambiguous grammars. However, adoption of GLR has been slowed by high constant-factor overheads and the lack of a general, user-defined action interface. In this paper we present algor...

Oxygen influences behaviour in many organisms, with low levels (hypoxia) having devastating consequences for neuron survival. How neurons respond physiologically to counter the effects of hypoxia is not fully understood. Here, we show that hypoxia regulates the trafficking of the glutamate receptor GLR-1 in C. elegans neurons. Either hypoxia or mutations in egl-9, a prolyl hydroxylase cellular ...

The generalized likelihood ratio (GLR) test has been proposed by Fan, Zhang and Zhang (2001) as a generally applicable method to test parametric, semiparametric or nonparametric models against nonparametric alternatives. It is a natural extension of the maximum likelihood ratio test for a parametric model and fully inherits the advantages of classical likelihood ratio tests. Both true likelihoo...

Some general results about the GLR tests, for testing simple hypothesis versus two-sided hypothesis, in the family with support dependent on the parameter, are obtained. In addition, we show that such GLR tests are equivalent to the UMP tests in the same problems. Moreover, we derive the general form of the UMP tests for testing an interval hypothesis versus two-sided alternative.

1. The moment expansion 2. Spectral expansion: reduction to GL2 3. Spectral expansion for GL2 4. Continuation and holomorphy at s′ = 0 for GL2 5. Spectral expansion for GLr 6. Continuation and holomorphy at s′ = 0 for GLr 7. Appendix: half-degenerate Eisenstein series 8. Appendix: Eisenstein series for GL2 9. Appendix: residues of degenerate Eisenstein series for Pn−1,1 10. Appendix: degenerate...

This paper presents an approach to identify Chinese base noun phrases. This method is based on GLR algorithm and extends GLR parsing algorithm further. It is a mixed approach that combines rule-based method and statistical method by using PCFG system. From the experiment results, this method is not only simple but also feasible and efficient to base noun phrases identification.

Ubiquitination occurs at synapses, yet its role remains unclear. Previous studies demonstrated that the RPM-1 ubiquitin ligase organizes presynaptic boutons at neuromuscular junctions in C. elegans motorneurons. Here we find that RPM-1 has a novel postsynaptic role in interneurons, where it regulates the trafficking of the AMPA-type glutamate receptor GLR-1 from synapses into endosomes. Mutatio...

GLR parsers have been criticized by various authors for their potentially large sizes. Other parsers also have individual weaknesses and strengths. Our heterogeneous parsing algorithm is based on GLR parsers that handle the size and other problems by partitioning the grammarduring compilingand assembling the partitioned sub-grammars during parsing. We discuss diierent parsers for diierent gramm...

After endocytosis, membrane proteins are often sorted between two alternative pathways: a recycling pathway and a degradation pathway. Relatively little is known about how trafficking through these alternative pathways is differentially regulated. Here, we identify UNC-108/Rab2 as a regulator of postendocytic trafficking in both neurons and coelomocytes. Mutations in the Caenorhabditis elegans ...