OBJECTIVES Knee joint distraction (KJD) is a novel, but poorly understood, treatment for osteoarthritis (OA) associated with remarkable 'spontaneous' cartilage repair in which resident synovial fluid (SF) multipotential mesenchymal stromal cells (MSCs) may play a role. We hypothesised that SF hyaluronic acid (HA) inhibited the initial interaction between MSCs and cartilage, a key first step to ...

We introduce $\sf{CosmoBit}$, a module within the open-source $\sf{GAMBIT}$ software framework for exploring connections between cosmology and particle physics with joint global fits. $\sf{CosmoBit}$ provides flexible studying various scenarios beyond $\Lambda$CDM, such as models of inflation, modifications effective number relativistic degrees freedom, exotic energy injection from annihilating...

This study compared surface roughness and gloss produced by different finishing/polishing procedures for two resin composites, Clearfil AP-X (AP-X) and Estelite Sigma (ES). A total of 70 composite discs (n=35 for each resin composite) were prepared and divided at random into seven finishing/polishing groups (n=5): glass-pressed control; using a super-fine-grit diamond bur (SF); using CompoMaste...

OBJECTIVES To evaluate the responsiveness of generic and mapped preference-based measures based on the anchor of global change in health condition of colorectal cancer (CRC) patients. STUDY DESIGN AND SETTING A baseline sample of 333 Chinese CRC patients was recruited between September 2009 and July 2010 and was surveyed prospectively at 6-month follow-up. Preference-based indices were derive...

OBJECTIVE To compare equine synovial fluid (SF) from injured and control joints for cartilage boundary lubrication function; concentrations of the putative boundary lubricant molecules hyaluronan (HA), proteoglycan 4 (PRG4), and surface-active phospholipids (SAPLs); relationships between lubrication function and composition; and lubrication restoration by addition of HA. METHODS Equine SF fro...

Sulphoraphane (SF), a naturally occurring isothiocyanate, is a potent anticarcinogen in animal experiments. The mechanism of action of sulphoraphane includes induction of Phase 2 detoxification enzymes, inhibition of carcinogen-activating Phase 1 enzymes, induction of apoptosis and cell cycle arrest, and anti-inflammation. We have recently found that it was accumulated in mammalian cells by up ...

Aim. Health state utilities measures are preference-weighted patient-reported outcome (PRO) instruments that facilitate comparative effectiveness research. One such measure, the SF-6D, is generated from the Short Form 36 (SF-36). This report describes a psychometric evaluation of the SF-6D in a cross-sectional population of lower extremity sarcoma patients. Methods. Patients with lower extremit...