OBJECTIVES To compare virological effectiveness in patients who continued on a virologically successful first-line boosted protease inhibitor (PI)-containing combination antiretroviral therapy (cART) regimen or who switched to a PI-free cART including efavirenz, nevirapine or abacavir. METHODS From the French Hospital Database on HIV, we selected 439 patients with undetectable viral load (VL)...

BACKGROUND World-wide, the notable expansion of HIV/AIDS treatment programs in resource-limited settings has lead to an increasing number of patients in need of second-line cART. To adequately address and prepare for this scenario, critical assessments of the outcomes of second-line cART are particularly relevant in settings where monitoring strategies may be inadequate. We evaluated virologic ...

BACKGROUND Although modern combination antiretroviral therapy (cART) regimens are better tolerated and less complex than earlier treatments, regimen modification or discontinuation remains a concern. METHODS We studied HIV Outpatient Study (HOPS) participants who initiated the first or second cART regimens during: 1996-1999, 2000-2003, 2004-2007, and 2008-2011. We analyzed regimen durability ...

OBJECTIVE Cocaine- and amphetamine-regulated transcript (CART) is widely expressed in the rat brain, especially in the hypothalamic nuclei and in the anterior pituitary. The aim of this study was to evaluate the effects of CART on pituitary hormone release in pituitary cell culture. MATERIAL AND METHODS The pituitary hormone release from pituitary cell culture after CART administration was in...

Twenty one males 17-22 months old took part in an experiment of the effects of shopping cart design on standing in the seat section of the cart and speed of standing. Two different cart designs were examined. It was predicted that standing would be more likely in the over-the-counter vs deep basket type of cart since the former is less confining because of a larger seating area and larger leg h...

Kastin, Abba J., and Victoria Akerstrom. Entry of CART into brain is rapid but not inhibited by excess CART or leptin. Am. J. Physiol. 277 (Endocrinol. Metab. 40): E901– E904, 1999.—Cocaineand amphetamine-regulated transcript (CART) is a new anorectic peptide found in the brain and periphery. It is closely associated with leptin, an anorectic agent saturably transported across the blood-brain b...

This paper extends a previous study that examined the role of enjoyment on the development of e-Loyalty by considering the role of race, income, and education on the enjoyment and development of e-Loyalty in women online shoppers. The goal of this research was to develop a better understanding of the online consumer by investigating women in relation to their e-commerce behaviors and perception...

An estimated 24,200 children younger than 15 years, 20,700 (85%) of whom were younger than 5 years, were treated in US hospital emergency departments in 2005 for shopping cart-related injuries. Approximately 4% of shopping cart-related injuries to children younger than 15 years require admission to the hospital. Injuries to the head and neck represent three fourths of all injuries. Fractures ac...

OBJECTIVE Determine whether HIV and combination antiretroviral therapy (cART) affect resting-state functional connectivity (rs-fc) between the striatum and the cortical regions. METHODS Forty-nine HIV-uninfected (HIV-) and 132 HIV-infected (HIV+) (65% receiving cART) patients underwent laboratory studies (current and nadir CD4 T-cell counts, and plasma HIV viral load), neuropsychological perf...