The discovery that c-fos, a proto-oncogene, has a role in pain, has triggered extensive research on the consequences of c-fos expression. It has been shown that c-fos, through its protein form, FOS, leads to expression of dynorphin gene and subsequently dynorphin protein which is implicated in the development of a pain state. This mini review looks at the properties of c-fos and the consequence...

The catalytic properties of Seqenzym® FT, a fungal fructosyltransferase heterologously expressed in yeasts, were investigated at temperature 55 °C and pH 5.5. initial rate measurements showed that the transfructosylation was only slightly inhibited by sucrose above concentration 1.5 M. A rather low level hydrolytic side activity observed even concentrations as 0.25 In progress curve experiments...

The ?-fructofuranosidase from the yeast Rhodotorula dairenensis (RdINV) produces a mixture of potential prebiotic fructooligosaccharides (FOS) levan-, inulin- and neo-FOS series by transfructosylation sucrose. In this work, gene responsible for activity was characterized its functionality proved in Pichia pastoris. amino acid sequence new protein contained most characteristic elements ?-fructof...

O frutooligossacarídeo (FOS) é um dos prebióticos mais relevantes da indústria de alimentos, além contribuir nas características sensoriais do produto, também conferem benefícios à saúde hospedeiro. efeito FOS frequentemente associado aos seus efeitos benéficos a microbiota intestinal. Este estudo tem como objetivo conceituar os frutooligossacarídeos em termos definição, inovação, tendências, i...

The immediate early gene c-Fos is reported to be regulated by Elk-1 and cAMP response element-binding protein (CREB), but whether nuclear factor (NF)-κB is also required for controlling c-Fos expression is unclear. In this study, we determined how NF-κB's coordination with Elk/serum response factor (SRF) regulates c-fos transcription. We report that PMA strongly induced c-Fos expression, but tu...

The c-fos protooncogene is transcriptionally activated by a wide variety of agents including serum, growth factors, and phorbol esters. This induction is rapid and transient and is mediated through a number of identified promoter elements. Growth hormone (GH) is also known to induce transcription of c-fos in a variety of cell types including NIH 3T3 fibroblasts and 3T3-F442A preadipocytes. To i...

Proto-oncogene c‑Fos (c‑Fos) is frequently used to detect a pathogenesis in central nervous system disorders. The present study examined changes in the immunoreactivity of c‑Fos in the paraventricular nucleus of the hypothalamus (PVNH) and paraventricular nucleus of the thalamus (PVNT) following myocardial infarction (MI) in rats. Infarction in the left ventricle was examined by Masson's trichr...

Methylmercury (MeHg) exposure during pregnancy is a concern because of its potential health risks to fetuses. Intestinal microbiota has important roles in the decomposition and fecal excretion MeHg. We investigated effect nondigestible saccharides on accumulation Hg after MeHg exposure. Female BALB/cByJ mice were fed basal diet or same supplemented with 5% fructooligosaccharides (FOS) 2.5% gluc...