Breast cancer progression is driven by altered gene expression. We show that the RIN1 gene, which encodes a RAS effector regulating epithelial cell properties, is silenced in breast tumor cell lines compared with cultured human mammary epithelial cells. We also report that RIN1 is often reduced in human breast tumor cells compared with morphologically normal breast glandular cells. At least two...

The information available to modern autonomous systems is often in the form of streams. As the number of sensors and other stream sources increases there is a growing need for incremental reasoning about the incomplete content of sets of streams in order to draw relevant conclusions and react to new situations as quickly as possible. To act rationally, autonomous agents often depend on high lev...

Both human epidermal growth factor receptor 2 (HER-2/neu) and VEGF overexpression correlate with aggressive phenotypes and decreased survival among breast cancer patients. Concordantly, the combination of trastuzumab (anti-HER2) with bevacizumab (anti-VEGF) has shown promising results in preclinical xenograft studies and in clinical trials. However, despite the known antiangiogenic mechanism of...

BACKGROUND Ginsenoside Rp1 (G-Rp1) is a novel ginsenoside derived from ginsenoside Rk1. This compound was reported to have anticancer, anti-platelet, and anti-inflammatory activities. In this study, we examined the molecular target of the antiproliferative and proapoptotic activities of G-Rp1. METHODS To examine the effects of G-Rp1, cell proliferation assays, propidium iodine staining, prote...

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In a Phase III trial for HER2-positive breast cancer (the CLEOPATRA study), the triple-drug combination arm of pertuzumab plus trastuzumab plus docetaxel showed significantly longer progression-free survival and overall survival than did the trastuzumab plus docetaxel arm. In this study, we investigated the mechanism of action of the triple-drug combination therapy in vivo. For this purpose, we...

We investigated the potential of the pH-sensitive dye, CypHer5E, conjugated to Herceptin (pH-Her) for the sensitive detection of breast tumors in mice using noninvasive time-domain near-infrared fluorescence imaging and different methods of data analysis. First, the fluorescence properties of pH-Her were analyzed as function of pH and/or dye-to-protein ratio, and binding specificity was confirm...

The information available to modern autonomous systems is often in the form of streams. As the number of sensors and other stream sources increases there is a growing need for incremental reasoning about the incomplete content of sets of streams in order to draw relevant conclusions and react to new situations as quickly as possible. To act rationally, autonomous agents often depend on high lev...

در این مقاله، به‌منظور رفع برخی محدودیت‌های شناسایی ساختمان تصاویر چندطیفی، از دادة SAR به‌منزلة مکمل استفاده می‌شود. روش پیشنهادی، برای استفادة هم‌زمان اطلاعات مفید رادار و استراتژی مبتنی‌بر تلفیق تصاویر، با هدف ساختمان، مطرح همچنین، ازآن‌جاکه انتخاب ویژگی نقش بسزایی طبقه‌بندی عوارض دارد، اغلب روش‌های مرسوم رایج زمینه، مانند الگوریتم ژنتیک، نیازمند داده‌های آموزشی‌اند؛ اما دردسترس‌نبودن همیشگی...

Acid mine drainage can be generated by coal stockpile piles, especially if the sulfur content is high which have an impact on environmental health. The of runoff water pollution overcome treating wastewater using phytoremediation. author conducted a phytoremediation experiment Echinodorus palaefolius plants with samples taken from inlet KPL C PT Bukit Asam Tbk Unit Dermaga Kertapati in June - A...