Prenatal screening test for Down syndrome (DS) can be improved by discovery of novel biomarkers. A multiplex selected reaction monitoring (SRM) assay was developed to test previously identified thirteen candidate proteins in amniotic fluid (AF). One unique peptide was selected for each protein based on discovery data, while three MS/MS transitions were selected based on intelligent SRM results....

BACKGROUND We evaluated the responsiveness of patient-derived questionnaires and physical findings in evaluating recovery after treatment of ulnocarpal abutment syndrome. METHODS Patients were assessed at their initial visit to our clinic and again 3 months after the treatment. At each visit, patients completed a Short Form-36, the Japanese Society for Surgery of the Hand version of Disabilit...

The uncertainties of the mean diameters of the nominal 1.0 µm SRM(®) 1690 polystyrene spheres and of the nominal 0.3 µm SRM(®) 1691 polystyrene spheres are recomputed using the current NIST Guidelines for computing uncertainty. The revised expanded uncertainty (approximately 95 % confidence level) for SRM(®) 1690 polystyrene spheres is equal to 0.005 µm compared to previous value of 0.008 µm. T...

Statistically distinguishing density-dependent from density-independent populations and selecting the best demographic model for a given population are problems of primary importance. Traditional approaches are PBLR (parametric bootstrapping of likelihood ratios) and Information Criteria (IC), such as the Schwarz Information Criterion (SIC), the Akaike Information Criterion (AIC) or the Final P...

Sedimentary iron sulfide minerals play a key role in maintaining the oxygenation of Earth’s atmosphere over geological timescales; they also record critical geochemical information that can be used to reconstruct paleo-environments. On modern Earth, sedimentary iron sulfide mineral formation takes places in low-temperature environments and requires the production of free sulfide by sulfate-redu...

Storage Resource Managers (SRMs) are middleware components whose function is to provide dynamic space allocation and file management on shared storage components on the Grid[1,2]. SRMs support protocol negotiation and reliable replication mechanism. The SRM standard supports independent SRM implementations, allowing for a uniform access to heterogeneous storage elements. SRMs allow site-specifi...

Speech recognition in noisy environments improves when the speech signal is spatially separated from the interfering sound. This effect, known as spatial release from masking (SRM), was recently shown in young children. The present study compared SRM in children of ages 5-7 with adults for interferers introducing energetic, informational, and/or linguistic components. Three types of interferers...

As part of a collaboration with the National Institutes of Health's Office of Dietary Supplements and the Food and Drug Administration's Center for Drug Evaluation and Research, the National Institute of Standards and Technology has developed two standard reference materials (SRMs) representing different forms of saw palmetto (Serenoa repens), SRM 3250 Serenoa repens fruit and SRM 3251 Serenoa ...

HYPOTHESIS In children with bilateral cochlear implants (BiCIs), experience over a 1 to 3-year period can improve speech understanding and spatial unmasking of speech. BACKGROUND One reason for providing children with BiCIs is to improve spatial hearing abilities. Little is known about changes in performance with added bilateral experience, and the relation between sound localization and spat...

Spatial release from masking (SRM) was measured in groups of children with bilateral cochlear implants (BiCIs, average ages 6.0 and 7.9 yr) and with normal hearing (NH, average ages 5.0 and 7.8 yr). Speech reception thresholds (SRTs) were measured for target speech in front (0°), and interferers in front, distributed asymmetrically toward the right (+90°/+90°) or distributed symmetrically towar...