Asthma is a chronic inflammatory disease affecting the lung, characterized by breathing difficulty during an attack following exposure to an environmental trigger. Calcitonin gene-related peptide (CGRP) is a neuropeptide that may have a pathological role in asthma. The CGRP receptor is comprised of two components, which include the G-protein coupled receptor, calcitonin receptor-like receptor (...

Cellulose is recalcitrant to deconstruction to glucose for use in fermentation strategies for biofuels and chemicals derived from lignocellulose. In Neurospora crassa, the transcriptional regulator, CLR-2, is required for cellulolytic gene expression and cellulose deconstruction. To assess conservation and divergence of cellulase gene regulation between fungi from different ecological niches, w...

Speakers naturally adopt a special "clear" (CLR) speaking style in order to be better understood by listeners who are moderately impaired in their ability to understand speech due to a hearing impairment, the presence of background noise, or both. In contrast, speech intended for nonimpaired listeners in quiet environments is referred to as "conversational" (CNV). Studies have shown that the in...

BACKGROUND The treatment of Buruli ulcer (BU) that is caused by Mycobacterium ulcerans, is currently based on a daily administration of rifampin and streptomycin (RIF-STR). A fully oral intermittent regimen would greatly simplify its treatment on the field. METHODOLOGY/PRINCIPAL FINDINGS The objective of this study was to assess the bactericidal and sterilizing activities of intermittent oral...

Glycine is the simplest amino acid and is used as a metabolic product in some bacteria. However, an excess of glycine inhibits the growth of many bacteria, and it is used as a nonspecific antiseptic agent due to its low level of toxicity in animals. The effect of glycine on Helicobacter pylori is not precisely known. The present study was conducted to investigate (i) the effect of glycine on cl...

BACKGROUND Routine turning of critically ill patients is a standard of care. In recent years, specialized beds that provide automated turning have been introduced. These beds have been reported to improve lung function, reduce hospital-acquired pneumonia, and facilitate secretion removal. This trial was designed to measure the physiological effects of routine turning and respiratory therapy in ...

For the application of many statistical methods it is necessary to establish the measure of di erence to be used This measure has to be de ned in accordance with the nature of the data In this study we propose a measure of di erence when the data set is compositional We analyze its properties and we present examples to illustrate its performance INTRODUCTION It is well known that the usual diss...

Primary cilia and flagella are distinct structures with different functions in eukaryotic cells. Despite the fact that they share similar basic organization and architecture, a direct developmental continuity among them has not been reported until now. The primary cilium is a dynamic structure that typically assembles and disassembles during mitotic cell cycles, whereas the sperm axoneme is nuc...

Biogas is a renewable fuel generated in the anaerobic digestion of organic material. The expansion biogas as bioenergy source next decades leads to find new ways for its energy exploitation such Chemical Looping technologies. In this work, low-cost Fe-based residue was used oxygen carrier two processes with biogas, namely Combustion (CLC) and Reforming (CLR). CLC process focused on production C...

BACKGROUND Dual antiplatelet therapy using acetylsalicylic acid (ASA, aspirin) and clopidogrel is of great importance following coronary stenting. However, the variable platelet inhibitory effectiveness compromises the antithrombotic advantages provided by dual antiplatelet therapy. The aim of this single-center prospective study was to reduce the low response incidence of dual antiplatelet the...