Guanine nucleotide exchange factor H1 (GEF-H1), which couples microtubule dynamics to RhoA activation, is a microtubule-regulated exchange factor. Studies have shown that GEF-H1 can be involved in various cancer pathways; however, the clinical significance of GEF-H1 expression and functions in melanoma has not been established. In this study, we investigated the relationship between clinical ou...

This study investigated genetic polymorphism related to anthocyanin composition variation in lisianthus (Eustoma grandiflorum) flower petals. Three different bands were detected by genomic polymerase chain reaction using specific primers based on the reported flavonoid 3',5'-hydroxylase (F3'5'H) gene sequence. Our revealed that they allelic. They named F3'5'H1-1, F3'5'H1-2, and f3'5'h1-2. F3'5'...

پژوهش حاضر به بررسی این مسأله می‌پردازد که چگونه نوعِ متد آموزشی می‌تواند بر میزان اضطراب زبانی دانشجویان زبان‌های خارجی تأثیر بگذارد. یک گروه 40 نفره از دختر و پسر در سطح پیش‌دانشگاهی به‌عنوان جامعه آماری انتخاب شدند. آموزش زبان فرانسه دو هفته‌ی اول، طریق گرامر-ترجمه انجام شد. پایان هفته تست تعیین مقیاس کلاس خارجی: FLCAS، بعمل آمد. دوم نوع رویکرد کنشی تغییر یافت. پس مجدداً فراگیران نتایج حاصله ن...

c-Myc is a nuclear protein with important roles in cell transformation, cell proliferation, and gene transcription. It has been previously shown that a 14-amino acid (aa) modified peptide (H1-S6A,F8A) derived from the helix 1 (H1) carboxylic region of c-Myc can interfere in vitro with specific c-Myc DNA binding. Here, we have linked the above Myc-derived 14-aa peptide to a 16-aa sequence from t...

Nm23-H1 plays complex roles in the development of diverse cancers including breast carcinoma, high-grade lymphomas, and acute myeloid leukemia (AML). In the case of AML and lymphomas, serum Nm23-H1 protein is elevated with the highest levels correlating with poorest prognosis. A recent study identified that this association is most likely causal in AML and that Nm23-H1 acts as an AML cell survi...

We examined the distribution of the somatic subtypes of histone H1 and the variant subtype, H1(0), and their encoding mRNAs during oogenesis and early embryogenesis in the mouse. As detected using immunocytochemistry, somatic H1 was present in the nuclei of oocytes of 18-day embryos. Following birth, however, somatic H1 became less abundant in both growing and non-growing oocytes, beginning as ...

If D is C+ or D , then we prove that H1(D) is a Hermite regular coherent ring of weak global dimension 2 (the coherence was already proved in [4]). We show: there is a one-to-one equivalence between systems de ned by matrices with entries in H1(D) and coherent H1(D)-modules, coherent H1(D)-modules are stable by elementary algebraic operations, and thus, we can characterize the algebraic propert...

The evolutionarily conserved homeotic (Hox) genes are organized in clusters and expressed collinearly to specify body patterning during embryonic development. Chromatin reorganization and decompaction are intimately connected with Hox gene activation. Linker histone H1 plays a key role in facilitating folding of higher order chromatin structure. Previous studies have shown that deletion of thre...

RNase H1 from Halobacterium sp. NRC-1 (Halo-RNase H1) is characterized by the abundance of acidic residues on the surface, including bi/quad-aspartate site residues. Halo-RNase H1 exists in partially folded (I) and native (N) states in low-salt and high-salt conditions respectively. Its folding is also induced by divalent metal ions. To understand this unique folding mechanism of Halo-RNase H1,...