The success of genome-wide association studies (GWASs) has enabled us to improve risk assessment and provide novel genetic variants for diagnosis, prevention, and treatment. However, most variants discovered by GWASs have been reported to have very small effect sizes on complex human diseases, which has been a big hurdle in building risk prediction models. Recently, many statistical approaches ...

Sea level is projected to rise in the coming centuries as a result of a changing climate. One of the major uncertainties is the projected contribution of the ice sheets in Greenland and Antarctica to sea-level rise (SLR). Here, we study the impact of different shapes of uncertainty distributions of the ice sheets on so-called sea-level allowances. An allowance indicates the height a coastal str...

Accurate sea-level rise (SLR) vulnerability assessments are essential in developing effective management strategies for coastal systems at risk. In this study, we evaluate the effect of combining vertical uncertainties in Light Detection and Ranging (LiDAR) elevation data, datum transformation and future SLR estimates on estimating potential land area and land cover loss, and whether including ...

Rising sea levels increase the probability of future coastal flooding. Many decision-makers use risk analyses to inform the design of sea-level rise (SLR) adaptation strategies. These analyses are often silent on potentially relevant uncertainties. For example, some previous risk analyses use the expected, best, or large quantile (i.e., 90%) estimate of future SLR. Here, we use a case study to ...

A multiuser multiple-input multiple-output (MIMO) downlink communication system is analyzed in a Rayleigh fading environment. The approximate closed-form expressions for the probability density function (PDF) of the signal-to-leakage ratio (SLR), its average, and the outage probability have been derived in terms of the transmit beamformer weight vector. With the help of some conservative deriva...

Laser ranging is an indispensable independent tool for validating the precise orbits determined for GNSS satellites using microwave pseudorange observations since decades. SLR allowed it to identify orbit modeling issues. Including albedo radiation pressure and antenna thrust, among others, into the GPS orbit model allowed it to basically eliminate the observed SLR bias. For the first Galileo s...

OBJECTIVE To use self-reported disability (Roland-Morris Disability Questionnaire [RMDQ]) to assess the criterion validity of straight leg raising (SLR) test and flexion range of motion (ROM) (fingertip-to-floor test) before and after stratification by sex and presence/absence of radicular pain. DESIGN Cross-sectional study. SETTING Outpatient physical therapy clinic. PARTICIPANTS Subject...

A best evidence topic in thoracic surgery was written according to a structured protocol. The question addressed was 'Is stereotactic ablative radiotherapy equivalent to sublobar resection in high-risk surgical patients with Stage I non-small cell lung cancer?'. Altogether over 318 papers were found, of which 18 represented the best evidence to answer the clinical question. The authors, journal...

and the assumptions are that the e, are independently normally distribtited with mean zero and (common) variance a^, e,~NID (0,(7̂ ). Focusing first on the structure of the model itself (Fig. 1), to test H:)8=0, is to test no change versus linear change and thus, according to the model, to reject H is to conclude that linear change has occurred, i.e., progressive change at a constant rate. To th...

We present Stellar Locus Regression (SLR), a method of directly adjusting the instrumental broadband optical colors of stars to bring them into accord with a universal stellar color-color locus, producing accurately calibrated colors for both stars and galaxies. This is achieved without first establishing individual zeropoints for each passband, and can be performed in real-time at the telescop...