The onset of spontaneous seizures in the pilocarpine model of epilepsy causes a hyperpolarized shift in the voltage-dependent activation of hyperpolarization-activated cyclic nucleotide-gated (HCN) channel-mediated current (Ih) in CA1 hippocampal pyramidal neuron dendrites, contributing to neuronal hyperexcitability and possibly to epileptogenesis. However, the specific mechanisms by which spon...

Alteration in hydrocyanic acid potential (HCN-p) of the forage is one of the important objectives in sudangrass [Sorghum sudanense (Piper) Stapf] breeding programs. The effectiveness of recurrent phenotypic selection for increasing or decreasing HCN-p in sudangrass was evaluated in two cycles of individual plant selection in the cultivar 'Greenleaf. In cycle 1, HCNp means of the high and low po...

Currently hydrogen cyanide (HCN) is industrially produced in the Czech Republic (Lucebni zavody Draslovka Kolin) and is extensively used for Czech mill fumigation. Therefore we evaluated the potential of HCN fumigant for treatment of wooden transport packages (pallets). We tested the penetration of HCN trough wooden pallet materials using gas chromatography. The preliminary results on biologica...

The experiments seem to indicate that the toxicity of HCN and KCN for amebae is due to their effect on the cell membrane and not on the internal protoplasm. Concentrated solutions (N/10-N/300) of HCN or KCN produce an initial increase in viscosity of the protoplasm of amebae (immersed) which is followed by liquefaction and disintegration of the cell. Dilute solutions of HCN or KCN decrease the ...

Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels are reverse voltage-dependent, and their activation depends on the hyperpolarization of the membrane and may be directly or indirectly regulated by the cyclic adenosine monophosphate (cAMP) or other signal-transduction cascades. The distribution, quantity and activation states of HCN channels differ in tissues throughout the bod...

We detect HCN J=5-4 emission from the ultraluminous quasar APM08279+5255 at z=3.911 using the IRAM Plateau de Bure interfer-ometer. This object is strongly gravitationally lensed, yet still thought to be one of the most intrinsically luminous objects in the Universe. The new data imply a line luminosity L ′ HCN (J=5−4) = 4.0 ± 0.5 × 10 10 K km s −1 pc 2. The ∼ 440 km s −1 full width half maximu...

There is increasing interest in using the cyanogenic properties of Pseudomonas aeruginosa to develop a nonmicrobiological method for its detection. Prior to this, the variation in cyanide production between different P. aeruginosa strains needs to be investigated. Hydrogen cyanide (HCN) released into the gas phase by 96 genotyped P. aeruginosa samples was measured using selected ion flow tube-m...

Hyperpolarization-activated cyclic nucleotide-gated (HCN) ion channels are expressed in several tissues throughout the body, including the heart, the CNS, and the retina. HCN channels are found in many neurons in the retina, but their most established role is in generating the hyperpolarization-activated current, I(h), in photoreceptors. This current makes the light response of rod and cone pho...

Hydrogen cyanide (HCN) is a ubiquitous molecule in the Universe. It is a compound that is easily produced in significant yields in prebiotic simulation experiments using a reducing atmosphere. HCN can spontaneously polymerise under a wide set of experimental conditions. It has even been proposed that HCN polymers could be present in objects such as asteroids, moons, planets and, in particular, ...

The hyperpolarization-activated/cyclic nucleotide (HCN)-gated channels make important contributions to neural excitability. In prefrontal cortex, HCN channels are localized on the distal dendrites of layer V pyramidal neurons and decrease neural excitability when they are open. In the present study, using whole-cell voltage clamp recordings, the effect of an arousal peptide, orexin A, on HCN cu...