© A m In this first issue of Intensive Care Medicine Experimental, two related studies describe the effects of antibodies directed against adrenomedullin (ADM), a vasoactive peptide that is released from various tissues during systemic inflammation, in murine sepsis. ADM, derived from a larger precursor peptide (pro-ADM), is released into the circulation during systemic inflammation, and the hi...

AIM Besides surgical treatment, systematic chemotherapy plays a crucial role in HCC treatment, especially for patients with advanced HCC. However, none of the single-drug-treatment strategies have shown significant survival benefit due to a high incidence rate of chemoresistance. This study was designed to observe the effect of small interfering of RNA (SiRNA) targeting multidrug resistance-rel...

OBJECTIVE Elevated plasma adrenomedullin (ADM) levels are associated with cardiovascular diseases. Single nucleotide polymorphisms (SNPs) in the gene encoding ADM (ADM) are associated with plasma ADM levels. The presence of a nuclear factor for interleukin-6 (IL-6) expression binding site in the promoter region of the ADM gene suggests a possible relationship between the expression of the ADM a...

Image inpainting in wavelet domain refers to the recovery of an image from incomplete and/or inaccurate wavelet coefficients. To reconstruct the image, total variation (TV) models have been widely used in the literature and they produce high-quality reconstructed images. In this paper, we consider an unconstrained TV-regularized, l2-data-fitting model to recover the image. The model is solved b...

The aim of this study was to analyze the viability of using an acellular dermal matrix (ADM) as a reinforcement material for peripheral corneal thinning disease. The complete removal of cell components was confirmed by hematoxylin and eosin (H&E) and 4',6-diamidino-2-phenylindole (DAPI) staining. Transmission electron microscopy determined that the stromal structure was well preserved. Uniaxial...

We propose p acket-selective photonic add/drop multiplexing (P-ADM), which can determine the source and de stination addresses in the packet header based upon optical code correlation and its novel application to ultrahighspeed optical data networking in LAN and MAN. It is distinct from conventional wavelength ADM (λ-ADM) in the traffic granularity, in that P-ADM can individually handle the pac...

Multidrug-resistance is a major obstacle facing cancer chemotherapy. This paper demonstrates that novel compound Ophiobolin-O reverses MCF-7/ADR resistance to adriamycin (ADM). The IC50 of ADM treated MCF-7 cells was 2.02 ± 0.05 µM and 74.00 ± 0.18 µM treated MCF-7/ADR cells, about 37-fold, compared to the former. However, 0.1 µM Ophiobolin-O (less than 20% inhibition concentration) combined wi...

PURPOSE Gingival recession is a major esthetic concern and may lead to root sensitivity during periodontal treatment. Coronally advanced flaps (CAFs) with and without acellular dermal matrix (ADM) are widely used in root coverage procedures. The aim of this study was to analyze the efficacy of CAF in combination with ADM in the treatment of gingival recession. METHODS PubMed, The Cochrane Lib...

The aim of the present study was to investigate whether placental and fetal membrane AdM (adrenomedullin) mRNA expression changes with gestation and human labour, as we have previously found labour-associated changes in AdM content in fetal membranes [Al-Ghafra, Gude, Brennecke and King (2003) Clin. Sci. 105, 419-423]. Placentas and fetal membranes were collected either at term or pre-term from...

Adriamycin (ADM) inhibited the beating of cultured mouse embryo myocardial cells doseand time-dependently and subsequently lysed the cells. Fifty percent inhibition of beating cell number was observed when cultures were exposed to 430-520 ƒÊm ADM for 0.5 h, 70-100 ƒÊm ADM for 4 h and 3.5 ƒÊm for 36 h. When cultures were exposed to 3.5 ƒÊm 3H-ADM, the radioactivity in the cells reached almost th...