Experimental gliomas attract hematopoietic progenitor cells (HPC) in vivo. HPC are therefore promising candidates for a cell-based delivery of therapeutic molecules to experimental gliomas. A therapeutic application requires efficient genetic manipulation of the cellular vector and a lack of tumorigenicity. Here, we studied the impact of lenti-viral transduction on the glioma tropism of human o...

Conditioned place preference (CPP) is a learning paradigm requiring formation of associations between reward and particular locations. White and McDonald (Behav Brain Res 1993;55:269-281) demonstrated that amygdala (AMG) lesions impair, while fornix (Fx) lesions enhance learning of this task. In the present experiments, we replicated the effects of AMG and Fx lesions, but we also found that com...

Background and Purpose—Hypoxia preconditioning (HPC), rapid or delayed, has been reported to induce neuroprotection against subsequent severe stress. Because -opioid receptor (DOR) plays an important role in delayed HPC-induced neuroprotection against severe hypoxic injury, we asked whether DOR is also involved in the rapid HPC-induced neuroprotection. Methods—Cultured rat cortical neurons at c...

OBJECTIVES The loss of effectiveness of ischaemic preconditioning in protecting old hearts from ischaemia/reperfusion damage is thought to be due to low sirtuin 1 levels in old hearts. We sought to determine whether resveratrol (RES), an activator of sirtuin 1, would restore this protection to that seen with ischaemic preconditioning in young hearts. METHODS A Langendorff heart perfusion mode...

Linux containers in the commercial world are changing the landscape for application development and deployments. Container technologies are also making inroads into HPC environments, as exemplified by NERSC’s Shifter and LBL’s Singularity. While the first generation of HPC containers offers some of the same benefits as the existing open container frameworks, like CoreOS or Docker, they do not a...

Programming tools for High Performance Computing are lagging behind the tools that have improved the productivity of desktop programmers. The increasing complexity of HPC codes, the growing number of cores that they must utilize, their long life-span, and the plethora of desirable source code optimizations and hardware platforms make HPC codes hard to maintain. Refactoring tools can enable HPC ...

Cloud computing has emerged as a new paradigm in large-scale computing. Highperformance computing (HPC) is an important research tool for a variety of fields. HPC requires a large investment in specialized computing infrastructure. While these costs could be alleviated by commercial cloud computing environments, standard clouds have extremely variable latency and reliability characteristics and...

H uman leukocyte antigen (HLA) matching is critically important for successful hematopoietic progenitor cell (HPC) transplantation because the rates of engraftment and transplant outcomes are strongly influenced by the degree of match. This is largely because HLA antigens are expressed on immature pluripotent stem cells. In contrast, ABO incompatibility is not a barrier to successful HPC transp...