BACKGROUND The movement of macromolecules through the nuclear pores requires energy and transport receptors that bind both cargo and nuclear pores. Different molecules/complexes often require different transport receptors. The signal recognition particle (SRP) is a conserved cytosolic ribonucleoprotein that targets proteins to the endoplasmic reticulum. Previous studies have shown that the expo...

The signal recognition particle database (SRPDB) is located at the University of Texas Health Science Center at Tyler and includes tabulations of SRP RNA, SRP protein and SRP receptor sequences. The sequences are annotated with links to the primary databases. They are ordered alphabetically or phylogenetically and are available in aligned form. As of September, 1998, there were 108 SRP RNA sequ...

Signal recognition particle (SRP) plays a central role in the delivery of classical secretory and membrane proteins to the endoplasmic reticulum (ER). All nascent chains studied to date dissociate from SRP once released from the ribosome, thereby supporting a strictly cotranslational mode of action for eukaryotic SRP. We now report a novel post-translational function for SRP in the targeting of...

Efficient and accurate protein localization is essential to cells and requires protein-targeting machineries to both effectively capture the cargo in the cytosol and productively unload the cargo at the membrane. To understand how these challenges are met, we followed the interaction of translating ribosomes during their targeting by the signal recognition particle (SRP) using a site-specific f...

The aim was to assess whether or not photodynamic therapy (PDT) with adjunctive scaling-and-root-planing (SRP) is effective in the treatment of periodontitis under immunocompromised conditions. PubMed/Medline and Google-Scholar databases were searched from 1967 to May 2013 using various key words. Six studies (five experimental and one clinical) were included. In the clinical study, SRP with PD...

objectives: scaling and root planing (srp) is one of the most commonly used procedures during periodontal treatment. the aim of this study was to evaluate the root surface roughness after srp with erbium: yttrium aluminum garnet (er:yag) laser compared to ultrasonic and hand instruments.   materials and methods: in this experimental study, 56 extracted sound single-rooted teeth with moderate le...

Signal recognition particle (SRP) is a ribonucleoprotein that functions in the targeting of ribosomes synthesizing presecretory proteins to the ER. SRP binds to the signal sequence as it emerges from the ribosome, and in wheat germ extracts, arrests further elongation. The translation arrest is released when SRP interacts with its receptor on the ER membrane. We show that the delay of elongatio...

Signal recognition particle (SRP), a small ribonucleoprotein required for targeting secretory proteins to the ER, has three known functions: signal recognition, elongation arrest, and translocation promotion. Because SRP is inactivated by the sulfhydryl alkylating reagent N-ethylmaleimide (NEM), we have attempted to establish structure-function relationships within SRP by assembling particles i...

background and aims. the aim of this investigation was to compare clinical and microbiological effectiveness of ad-junctive photodynamic therapy (pdt) in the treatment of periodontitis. materials and methods. twenty-four subjects (14 women and 10 men) diagnosed with moderate to severe chronic periodontitis underwent scaling and root planing (srp). one tooth in each quadrant (probing depth >4 mm...

introduction: the aim of the present study was to investigate the effects of srp assisted by the two clinical treatment methods of diode laser or chlorhexidine gel applications in comparison with srp alone. methods: eight patients with moderate to severe chronic periodontitis, each with at least three pockets 4–7 mm deep, were selected for this study. over 66 pockets were selected and randomly ...