Abstract: The aim of the present study was directed to investigate therapeutic efficacy intraperitoneally injected curcumin as anticarcinogenic treatment modality on 7,12-dimethylbenz[a]anthracene (DMBA) induced hamster buccal pouch(s) (HBP(s)) carcinoma. Subjects and methods: Thirty Syrian male hamsters, five weeks old, weighing 90-130g were divided into three group(s) (G(s)): A, B, C. G-A (ne...

Background: Cancer is one of leading cause death number 2 in the world,or six deaths 2018. The incidance breast cancer as much 11,6% and are 6,6% Medical plant be expacted has potential an anticancer with minimal side effects when used at correct dosage, timing it properly.
 Objectives: To determine effect garlic extract on histopathological picture female Sprague-Dawley rats induced DMBA....

Many mouse models of breast cancer have been developed that closely replicate human breast cancer subtypes at the genomic level. In order to develop vaccines that could prevent a broad spectrum of breast cancer subtypes, a combination of different spontaneous tumor models are needed. Transgenic models are available that mimic HER2+/luminal breast cancer (TgMMTV-Neu) and triple negative/basal-li...

BACKGROUND Non-steroidal anti-inflammatory drugs (NSAIDs) act by inhibition of cyclooxygenase-2 (COX-2), which is overexpressed in cancer. The role of COX-2 and apoptosis were evaluated in 9,10-dimethylbenz(a)anthracene (DMBA)-induced lung cancer in rat and chemoprevention with indomethacin, a traditional NSAID and etoricoxib, a selective COX-2 inhibitor. METHODS The animals were divided into...

The formation of DNA adducts from [3H]-7-hydroxymethyl-12-methylbenz(a)anthracene (7-OHM-12-MBA) and [3H]-7,12-dimethylbenz(a)anthracene (DMBA) in the epidermis of Sencar mice was analyzed. Comparison of Sephadex LH-20 chromatographic profiles of DNA samples isolated from mice treated with DMBA or 7-OHM-12-MBA suggested that the DMBA-treated animals contained DNA adduct(s) derived from the furt...

We examined the effect of S-allylcysteine (SAC), a water-soluble garlic constituent, on cytokeratin expression, a sensitive and specific marker for differentiation status during 7,12-dimethylbenz[a]anthracene (DMBA)-induced hamster buccal pouch (HBP) carcinogenesis in male Syrian hamsters. Hamsters were divided into four groups of six animals each. Animals in group 1 were painted with a 0.5% so...

7,12-Dimethylbenz(a)anthracene (DMBA) is a potent carcinogen that induces immunosuppression of both humoral and cell-mediated immunity in mice and other species. Previous studies have shown that CYP1B1 is required for bone marrow toxicity produced by DMBA in mice. Therefore, the purpose of these studies was to determine whether CYP1B1 was required for spleen cell immunotoxicity. Female C57BL/6N...

We reported earlier that replacement of casein by soy protein in the diets rats exposed to carcinogen, dimethylbenz[a]anthracene (DMBA), not only delayed initiation breast tumor but also had a protective effect against development aggressive tumor. The aim this study was elucidate molecular mechanism which offers these beneficial effects. Tumor developed gavage administration single dose 80 mg/...

The modulation in biochemical status of skin and hepatic tissue at the time point of commencement of promotion stage of skin carcinogenesis in mice and its intervention with aqueous Azadirachta indica leaf extract (AAILE) were investigated. 7,12-Dimethylbenz(a)anthracene (DMBA, 500 nmol/100 ul of acetone) was applied topically for 2 weeks (twice weekly), followed by phorbol-12-myristate-13-acet...