STUDY QUESTION What are the direct effects of androgens on primate follicular development and function at specific stages of folliculogenesis? SUMMARY ANSWER Androgen addition altered primate follicle survival, growth, steroid and anti-Müllerian hormone (AMH) production, and oocyte quality in vitro, in a dose- and stage-dependent manner. WHAT IS KNOWN ALREADY Androgens have local actions in...

A specific, accurate, and sensitive double antibody radioimmunoassay for measuring human apolipoprotein (apo) C-111 has been developed. Anti-apoC-111, developed in rabbits cross-reacted completely with apoC-111 subspecies. Analytical isoelectric focusing of delipidated triglyceride-rich lipoproteins (TRL) was done to assess the percentage of total apoC-111 mass comprised by apoC-HI,, C-IIIl, an...

Therapy-related leukemia (TRL) has been reported to occur after treatment with alkylating agents and/or topoisomerase II inhibitors. Oxaliplatin (OXP) is used as a key drug for the treatment of colorectal cancer (CRC). Cisplatin and carboplatin have been linked with TRL, but the involvement of OXP is questionable. A 74-year-old male was diagnosed with peritoneal metastasis from CRC in July 2011...

Plasma lipoprotein changes were monitored for 12 hr after a fat-rich meal (1 g of fat/kg body weight) in 22 subjects (9 males, 13 females, 22-79 yr old). Plasma triglyceride, measured hourly, peaked once in some subjects, but twice or three times in others. The magnitude of postprandial triglyceridemia varied considerably between subjects (range: 650-4082 mg.hr/dl). Males tended to have greater...

After receptor-mediated endocytosis, the intracellular fate of triglyceride-rich lipoproteins (TRLs) is far more complex than the classical degradation pathway of low-density lipoproteins. Once internalized, TRLs disintegrate in peripheral endosomes, followed by a differential sorting of TRL components. Although core lipids and apolipoprotein B are targeted to lysosomes, the majority of TRL-der...

CONTEXT Familial hypobetalipoproteinemia (FHBL) is a codominant disorder of lipoprotein metabolism characterized by decreased plasma concentrations of low-density lipoprotein (LDL)-cholesterol and apolipoprotein B (apoB). OBJECTIVE The objective was to examine the effect of heterozygous APOB L343V FHBL on postprandial triglyceride-rich lipoprotein (TRL) and fasting lipoprotein metabolism. M...

BACKGROUND Moderate alcohol consumption increases plasma HDL and lowers cardiovascular disease risk while transiently enhancing postprandial lipemia. OBJECTIVE We hypothesized that the alcohol-mediated increase in postprandial triacylglycerol-rich lipoproteins (TRLs) and their clearance elevate HDL cholesterol and reverse cholesterol transport. DESIGN We determined the effect in normolipide...

زمینه و هدف: کشتی ورزشی برخوردی با انقباض‌های برون‌گرای مکرر شدت بالاست. چنین فعالیت‌هایی که شدید انجام می‌گیرد، اختلالات مکانیکی متابولیکی همراه است. بالایی از فعالیت در به‌طور چشمگیری به تولید ناگهانی گونه‌های اکسیژن واکنش‌پذیر بنیان‌های آزاد حین رقابت بازیافت پس هر مسابقه منجر می‌شود، به‌طوری‌که حتی ممکن است طی این دسته فعالیت‌ها، ذخیرة ضداکسایشی به‌شدت کاسته تخلیه شود به‌دنبال ناکارامدی دست...