نتایج جستجو برای: سلولهای t مهندسی شده car t cell
تعداد نتایج: 2678626 فیلتر نتایج به سال:
Engineering T cells with a chimeric antigen receptor (CAR) that reprograms their selectivity and signalling has recently emerged as one of the most promising therapeutic approaches for treating cancers. The initial emergence evolution this treatment significantly contributed to its success. However, it is not known if advancement technology accompanied any socio- economic or ethical concerns. T...
T cell immunotherapy is emerging as a powerful strategy to treat cancer, and may offer new opportunities to improve outcomes for patients with glioblastoma (GBM). Our group has developed a chimeric antigen receptor (CAR) T cell immunotherapy for GBM targeting IL-13 receptor a2 (IL13Ra2), a cell surface receptor over-expressed by the majority of high-grade gliomas. Towards this end, we have opti...
Chimeric antigen receptor (CAR) T cells can produce durable remissions in hematologic malignancies that are not responsive to standard therapies. Yet the use of CAR T cells is limited by potentially severe toxicities. Early case reports of unexpected organ damage and deaths following CAR T-cell therapy first highlighted the possible dangers of this new treatment. CAR T cells can potentially dam...
The majority of chimeric antigen receptor (CAR) T-cell research has focused on attacking cancer cells. Here, we show that targeting the tumor-promoting, nontransformed stromal cells using CAR T cells may offer several advantages. We developed a retroviral CAR construct specific for the mouse fibroblast activation protein (FAP), comprising a single-chain Fv FAP [monoclonal antibody (mAb) 73.3] w...
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