Background Cardiac magnetic resonance (CMR) imaging using phase sensitive inversion recovery (PSIR) late gadolinium enhancement (LGE) is the in vivo reference standard for assessing focal myocardial scar. Post-contrast T1-mapping by Modified Look-Locker Inversion recovery (MOLLI) can be used to generate a Synthetic PSIR LGE (SynLGE) image with an image contrast similar to conventional LGE image...

We characterized intrinsic and extrinsic specification of progenitors in the lateral and medial ganglionic eminences (LGE and MGE). We identified seven genes whose expression is enriched or restricted in either the LGE [biregional cell adhesion molecule-related/downregulated by oncogenes binding protein (Boc), Frizzled homolog 8 (Fzd8), Ankrd43 (ankyrin repeat domain-containing protein 43), and...

BACKGROUND The objective was to compare the value of late gadolinium enhancement (LGE) and end-diastolic wall thickness (EDWT) assessed by cardiovascular magnetic resonance (CMR) in predicting recovery of left ventricular function after coronary artery bypass surgery (CABG). METHODS We enrolled patients with coronary artery disease and left ventricular ejection fraction < 45% who were schedul...

Background Late gadolinium enhancement (LGE) is excellent for identifying focal lesions in the myocardium (necrosis, fibrosis), but diffuse homogeneous abnormalities are not readily detectable. Quantitative measurement of the myocardial extracellular volume (ECV) fraction using MRI has recently been validated histologically, and implemented for parametric imaging in patients. We hypothesized th...

INTRODUCTION AND OBJECTIVES In patients with hypertrophic cardiomyopathy, myocardial fibrosis can be detected by late gadolinium enhancement (LGE) on cardiac magnetic resonance imaging. We investigated the relationships between the extent of LGE, left ventricular morphology and function, and clinical characteristics. METHODS Both cine and gadolinium-enhanced magnetic resonance imaging were pe...

BACKGROUND Cardiac impairment is associated with high morbidity and mortality in immunoglobulin light chain (AL) type amyloidosis, for which early identification and risk stratification is vital. For myocardial tissue characterization, late gadolinium enhancement (LGE) is a classic and most commonly performed cardiovascular magnetic resonance (CMR) parameter. T1 mapping with native T1 and extra...

Background Interstitial deposition of amyloid fibrils in the heart causes thickening of atrial and ventricular walls. Although the presence of abnormal late gadolinium enhancement (LGE) in ventricular myocardium is well described, the significance of atrial LGE is less clear. The aim of this study is to describe the prevalence of atrial LGE in cardiac amyloidosis and to investigate potential as...

OBJECTIVE Myocardial fibrosis related to non-specific inflammation can be detected using late gadolinium-enhancement cardiovascular MR (LGE-CMR), which is an important prognostic indicator for dilated cardiomyopathy (DCM). The aims of this study were to define the prognostic factors for DCM with LGE-CMR, and to evaluate the impact of the prognostic factors on adverse effects. METHODS We perfo...

BACKGROUND There is a major unmet need to identify high-risk patients in myocarditis. Although decreasing cardiac and inflammatory markers are commonly interpreted as resolving myocarditis, this assumption has not been confirmed as of today. We sought to evaluate whether routine laboratory parameters at diagnosis predict dynamic of late gadolinium enhancement (LGE) as persistent LGE has been sh...

Methods We prospectively enrolled 32 subjects with a genetically confirmed diagnosis of MD2. Exclusion criteria were known cardiac diseases and contraindication for CMR. We assessed left-ventricular (LV) volumes, mass and function applying state of the art cine imaging using a 1.5 T Scanner. Late enhancement imaging (LGE; slice thickness (sth) 7 mm) was performed to detect myocardial fibrosis 1...