background: perforin is known to be important in cytolytic activity mediated by natural killer (nk) cells.   objective: to study the relationship between the efficiency of nk and lymphokine-activated killer (lak) cells activity, and the expression of perforin and hla class i molecules.   methods: lak cells were generated by in vitro culturing of human peripheral blood lymphocytes (pbls) in the ...

background: natural killer (nk) cells are the effector cells of innate immunity that respond to infection and tumor. interactions between killer cell immunoglobulin like receptors (kir) and human leukocyte antigen (hla) class i molecules regulate nk cells responses to eliminate infected and transformed cells. objective: to investigate the impact of kir genes, hla ligand genes, and kir-hla combi...

Background: NK (natural killer) and NKT (natural killer T) cells, as components of innate immune system, play a crucial role in tumor progression and dissemination. Objective: To investigate the percentages of NK cells, NKT cells, iNKT (invariant natural killer T) cells, total T lymphocytes as well as activated T lymphocytes, in tumor draining lymph nodes (TDLN...

The objective of this paper is to examine the asymptotic behavior persistence diagrams associated with Čech filtration. A diagram a graphical descriptor topological and algebraic structure geometric objects. We consider filtration over scaled random sample rn−1Xn={rn−1X1,…,rn−1Xn}, such that rn→0 as n→∞. treat point process establish their limit theorems in sparse regime: nrnd→0, In setting, we...

Una de las herramientas más novedosas en inmunoterapias adoptivas contra leucemias y tumores malignos es el uso del receptor antígeno quimérico “CAR”. El CAR ha sido ampliamente utilizada células T (células CAR-T) potenciando su eficacia reconocimiento eliminación tumores, obteniéndose a la fecha terapias basadas esta tecnología. No obstante, CAR-T llegan repercutir negativamente salud paciente...

Gene-engineered immune cell therapies have partially transformed cancer treatment, as exemplified by the use of chimeric antigen receptor (CAR)-T cells in certain hematologic malignancies. However, there are several limitations that need to be addressed target more types. Natural killer (NK) a type innate represent unique biology surveillance. In particular, NK obtained from heathy donors can s...

Transient stimulation with substance P (SP) induces endocytosis and recycling of the neurokinin-1 receptor (NK(1)R). The effects of sustained stimulation by high concentrations of SP on NK(1)R trafficking and Ca(2+) signaling, as may occur during chronic inflammation and pain, are unknown. Chronic exposure to SP (100 nm, 3 h) completely desensitized Ca(2+) signaling by wild-type NK(1)R (NK(1)Rw...