BACKGROUND Shear stress caused by arteriovenous fistula (AVF) enhances endothelium-dependent relaxation (EDR) but oxidized low-density lipoprotein (ox- LDL) counteracts its effect. Probucol, a lipid soluble antioxidant, may preserve EDR of AVF by limiting oxidation of LDL. METHODS Twenty New Zealand rabbits, fed with 2% cholesterol chow for 4 weeks, underwent AVF. They were then divided into ...

Exposure of isolated arteries to oxidatively modified low density lipoprotein (LDL) has been reported to suppress endothelium-dependent relaxation (EDR). To determine whether lipid degradation products in oxidized LDL contribute to impaired relaxation, we have tested the responsiveness of isolated rabbit aortas to endothelium-dependent relaxants (acetylcholine, ATP, and calcium ionophore A23187...

After a background discussion, life table construction and methodology are discussed, with references. Complete life tables are utilized for U.S. white men and women, based on the published data from birth to age 109, in the 1989-91 population. A previously published method is described for adding EDR to the population mortality rate q’ to derive a life table for a cohort with defined age, sex,...

BACKGROUND the mortality experience for structured settlement (SS) annuitants issued both standard (Std) and substandard (SStd) has been reported twice previously by the Society of Actuaries (SOA), but the 1995 mortality described here has not previously been published. We describe in detail the 1995 SS mortality, and we also discuss the methodology of calculating life expectancy (e), contrasti...

Geographic Information Systems (GIS) is a kind of computer software that allows people to work with digital maps in a fast and flexible way. In the past decade, more and more geography teachers have become interested in the possibilities of using GIS in secondary education. However, teaching with GIS is complex, and little is known about how to do so in an optimal way. Therefore, an Educational...

The paper presents the application of artificial neural network (ANN) to determine the end-depth-ratio (EDR) for a smooth inverted semicircular channel in all flow regimes (subcritical and supercritical). The experimental data were used to train and validate the network. In subcritical flow, the end depth is related to the critical depth, and the value of EDR is found to be 0.705 for a critical...

The most similar case may not always be the most appropriate one to guide a problem-solving process. It is often important that a retrieved past case can be easily adapted to a target problem. The presented work deals with the retrieval and adaptation in textual casebased reasoning (TCBR) where cases are described textually. In TCBR, it is common to use similarity-based retrieval methods from i...

The ribosomal frameshifting signal of the mouse embryonal carcinoma differentiation regulated (Edr) gene represents the sole documented example of programmed -1 frameshifting in mammalian cellular genes [Shigemoto,K., Brennan,J., Walls,E,. Watson,C.J., Stott,D., Rigby,P.W. and Reith,A.D. (2001), Nucleic Acids Res., 29, 4079-4088]. Here, we have employed site-directed mutagenesis and RNA structu...

A semiparametric regression model of a q-dimensional multivariate response y on a p-dimensional covariate x is considered. A new approach is proposed based on sliced inverse regression (SIR) for estimating the effective dimension reduction (EDR) space without requiring a prespecified parametric model. The convergence at rate √ n of the estimated EDR space is shown. The choice of the dimension o...