Hsa-miRNA-206 (miR-206), highly expressed in skeletal muscle, has recently been discovered to have anticancer properties in different tissues. However, the role of miR-206 on lung cancer is still ambiguous. In this study, we investigated the role of miR-206 on the development of lung cancer. The results indicated that miR-206 expression was suppressed in lung cancer tissues and very low levels ...

BACKGROUND The expression of microRNA-206 (miR-206) is high in skeletal muscle but low in most other tissues. The expression of miR-206 is increased in muscular dystrophy, suggesting its involvement in the pathogenesis of muscle diseases. To determine the role of miR-206 in muscle cell differentiation and explore a possible gene therapy vector, we constructed a miR-206 adenoviral expression vec...

MiR-206 is low expression in lung cancers and associated with cancer metastasis. However, the roles of miR-206 in epithelial-mesenchymal transition (EMT) and angiogenesis in lung cancer remain unknown. In this study, we find that hepatocyte growth factor (HGF) induces EMT, invasion and migration in A549 and 95D lung cancer cells, and these processes could be markedly inhibited by miR-206 overex...

Aims: The aim of this study is to investigate the role of miR-206 in propofol induced protective effects in cerebral ischemia/reperfusion injury and to explore its possible mechanism. Methods: Hypoxia/reoxygenation (H/R) model of mouse motoneuron-like cell line NSC-43 was established, and the expression miR-206 upon propofol treatment was analyzed by Realtime PCR. Cells were transfected with mi...

James C. McWilliams Department of Atmospheric Sciences and Institute of Geophysics and Planetary Physics University of California, Los Angeles Los Angeles, CA 90095-1565 Phone:(310)206-2829 Fax:(310)206-5219 Email:[email protected] Alexander Shchepetkin Institute of Geophysics and Planetary Physics University of California, Los Angeles Los Angeles, CA 90095-1567 Phone:(310)206-9381 Fax:(310)20...

Aspartame is a phenylalanine containing sweetener, added to foods and drinks, which avoided in phenylketonuria (PKU). However, the amount of provided by aspartame unidentifiable from food drinks labels. We performed cross-sectional online survey aiming examine accidental consumption PKU. 206 questionnaires (58% female) were completed. 55% respondents (n = 114) adults with PKU or their parent/ca...

MicroRNAs (miRNAs) have been investigated widely as key regulators of gene expression in different diseases by affecting the miRNA‑mediated regulatory function. Human enterovirus 71 (HEV71) can cause a series of human diseases, including encephalitis. Chemokine (C‑C motif) ligand 2 (CCL2) is one of the important genes involved in regulating inflammation. However, the mechanisms underlying HEV71...

Epidermal growth factor (EGF) receptor (EGFR)/MAPK signaling can induce a switch in MCF-7 breast cancer cells, from an estrogen receptor (ER) -positive, Luminal-A phenotype, to an ER negative, Basal-like phenotype. Although mechanisms for this switch remain obscure, Basal-like cancers are typically high grade and confer a poorer clinical prognosis. We previously reported that miR-206 and ER rep...

Micro-RNAs are small noncoding RNAs, which diminish the stability and/or translation of mRNAs. This study examined whether miR-206, previously shown to be elevated in estrogen receptor (ER) -negative breast cancer, regulates the expression of ER . Two putative miR-206 sites, (hER 1 and hER 2), were found in silico within the 3 -untranslated region of human ER mRNA. Transfection of MCF-7 cells w...