Ammoniagenesis and gluconeogenesis are prominent metabolic features of the renal proximal convoluted tubule that contribute to maintenance of systemic acid-base homeostasis. Molecular analysis of the mechanisms that mediate the coordinate regulation of the two pathways required development of a cell line that recapitulates these features in vitro. By adapting porcine renal epithelial LLC-PK1 ce...

The IPA Tactical Asset Allocation (TAA) model was developed over many years of financial and econometric research. The resulting model is a quantitative approach that allows for a disciplined investment strategy. To the best of our knowledge no other TAA model has ever created or combined metrics in the manner we use at IPA to produce our TAA signals. From the selection of inputs, to the quanti...

POLICY STATEMENT The primary goal of antenatal evaluation is to identify fetuses at risk for intrauterine injury and death so that intervention and timely delivery can prevent progression to stillbirth. It should be understood however, that despite widespread use of many tests, limited evidence exists to demonstrate effectiveness at improving perinatal outcomes with application of these tests. ...

Mechanical stretch can activate muscle and myotube protein synthesis through mammalian target of rapamycin complex 1 (mTORC1) signaling. While it has been established that tumor-derived cachectic factors can induce myotube wasting, the effect of this catabolic environment on myotube mechanical signaling has not been determined. We investigated whether media containing cachectic factors derived ...

Two kinds of carbon materials, i.e., graphene and graphene oxide (GO), were successfully incorporated into a lyotropic liquid crystal (LLC) matrix formed by n-dodecyl tetraethylene monoether (C12E4). The properties of graphene-C12E4 and GO-C12E4 LLC composites were characterized by UV-vis absorption, transmission electron microscopy (TEM) observations, polarized optical microscopy (POM) observa...

In the present work, we have explored the dynamics of different steps of photopyrolytic processes of an eminent anticancer drug topotecan (TPT) inside the biocompatible reverse hexagonal (HII), gyroid (Ia3d) cubic and diamond (Pn3m) cubic lyotropic liquid crystalline (LLC) phases. Both steady state and timeresolved area normalized emission spectrum (TRANES) demonstrate the generation of an exci...

A variety of vasoactive stimuli induce endothelial permeability through Rac1, a membrane of Rho small GTPases. Here, we determine whether tumor-secreted vasoactive stimulant through Rac1 inducing permeability contributes to hematogenous metastasis. Activation of Rac1 was assayed in human umbilical vein endothelial cells (HUVEC), transendothelial passages were measured by Transwell chambers, and...

Characterization of the stem-like properties of cancer stem cells (CSCs) remain indirect and qualitative, especially the ability of CSCs to undergo asymmetric cell division for self renewal and differentiation, a unique property of cells of stem origin. It is partly due to the lack of stable cellular models of CSCs. In this study, we developed a new approach for CSC isolation and purification t...

llc is a language based on C where parallelism is expressed using compiler directives. The llc compiler produces MPI code which can be ported to both shared and distributed memory systems. In this work we focus our attention in the llc implementation of the Workqueuing Model. This model is an extension of the OpenMP standard that allows an elegant implementation of irregular parallelism. We eva...